Apoptosis induced by Staphylococcus aureus in epithelial cells utilizes a mechanism involving caspases 8 and 3

Carla A. Wesson, James Deringer, Linda E. Liou, Kenneth W. Bayles, Gregory A. Bohach, William R. Trumble

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

In this study, we demonstrate that the mechanism by which Staphylococcus aureus induces apoptosis in bovine mammary epithelial (MAC-T) cells involves Caspases 8 and 3, two key components of a proteolytic cascade leading to apoptosis. In addition, internalized S. aureus induces expression of the inflammatory cytokines tumor necrosis factor alpha and interleukin-1β by MAC-T cells. These data suggest that the internalization of S. aureus could induce specific cellular responses in vivo that may ultimately impact the course of infection.

Original languageEnglish (US)
Pages (from-to)2998-3001
Number of pages4
JournalInfection and immunity
Volume68
Issue number5
DOIs
StatePublished - May 2000

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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