Application of image-guided surface coil P-31 MR spectroscopy to human liver, heart, and kidney

G. B. Matson, D. B. Twieg, G. S. Karczmar, T. J. Lawry, J. R. Gober, M. Valenza, M. D. Boska, M. W. Weiner

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Localized phosphorus-31 magnetic resonance (MR) spectroscopy in humans has previously been accomplished with surface coils by means of depth-resolved surface coil spectroscopy or rotating frame experiments in which the extent of tissue sampled critically depends on surface coil placement. The authors' goal was to modify the surface coil image-selected in vivo spectroscopy (ISIS) experiment to accomplish thee-dimensional volume selection through application of selective pulses in the presence of B0 gradients. Advantages of ISIS include the ability to use proton images to define the volume of interest (VOI) and reduced dependence on exact positioning of the surface coil. However, rapid replication of the surface coil ISIS experiment can cause spectral contamination from signals originating outside the VOI. A modified version of the ISIS experiment was developed to alleviate contamination under conditions of rapid replication. Applications of localized P-31 MR spectroscopy for observation of high-energy phosphorus metabolites are presented in human liver, heart, and transplanted and normal kidney.

Original languageEnglish (US)
Pages (from-to)541-547
Number of pages7
Issue number2
StatePublished - 1988

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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