Abstract
Structural genomics is poised to have a tremendous impact on traditional structure-based drug design programs. As a result, there is a growing need to obtain rapid structural information in a reliable form that is amenable to rational drug design. In this manner, NMR has been expanding and evolving its role in aiding the design process. A variety of NMR methodologies that cover a range of inherent resolution are described in the context of structure-based drug design in the era of structural genomics.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 113-123 |
| Number of pages | 11 |
| Journal | Journal of Structural and Functional Genomics |
| Volume | 2 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2002 |
| Externally published | Yes |
Keywords
- NMR
- NMR screening
- Protein structures
- Structural genomics
- Structure-based drug design
ASJC Scopus subject areas
- Structural Biology
- Biochemistry
- Genetics