Applications of NMR to structure-based drug design in structural genomics

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Structural genomics is poised to have a tremendous impact on traditional structure-based drug design programs. As a result, there is a growing need to obtain rapid structural information in a reliable form that is amenable to rational drug design. In this manner, NMR has been expanding and evolving its role in aiding the design process. A variety of NMR methodologies that cover a range of inherent resolution are described in the context of structure-based drug design in the era of structural genomics.

Original languageEnglish (US)
Pages (from-to)113-123
Number of pages11
JournalJournal of Structural and Functional Genomics
Volume2
Issue number2
DOIs
StatePublished - 2002
Externally publishedYes

Keywords

  • NMR
  • NMR screening
  • Protein structures
  • Structural genomics
  • Structure-based drug design

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Genetics

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