Approach to infection and disease due to adenoviruses in solid organ transplantation

Diana F. Florescu, Erica J. Stohs

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Purpose of reviewAdenoviruses are an important cause of morbidity and mortality of solid organ transplant patients and remain a clinical challenge with regard to diagnosis and treatment. In this review, we provide an approach to identification and classification of adenovirus infection and disease, highlight risk factors, and outline management options for adenovirus disease in solid organ transplant patients.Recent findingsAdditional clinical data and pathologic findings of adenovirus disease in different organs and transplant recipients are known. Unlike hematopoietic cell transplant recipients, adenovirus blood PCR surveillance and preemptive therapy is not supported in solid organ transplantation. Strategies for management of adenovirus disease continue to evolve with newer antivirals, such as brincidofovir and adjunctive immunotherapies, but more studies are needed to support their use.SummaryDistinguishing between adenovirus infection and disease is an important aspect in adenovirus management as treatment is warranted only in symptomatic solid organ transplant patients. Supportive care and decreasing immunosuppression remain the mainstays of management. Cidofovir remains the antiviral of choice for severe or disseminated disease. Given its significant nephrotoxic effect, administration of probenecid and isotonic saline precidofovir and postcidofovir infusion is recommended.

Original languageEnglish (US)
Pages (from-to)300-306
Number of pages7
JournalCurrent Opinion in Infectious Diseases
Issue number4
StatePublished - Aug 1 2019


  • adenovirus
  • cidofovir
  • solid organ transplantation

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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