Aqueous Humor Dynamics and Intraocular Pressure Elevation

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


A primary function of the production and circulation of aqueous humor is the maintenance of IOP at a healthy and stable level. When IOP becomes elevated, as seen in ocular hypertension, primary open-angle glaucoma, and various syndromes described in this chapter, it is always accompanied by a reduction in outflow facility. Changes in uveoscleral outflow are not consistent among the various syndromes. Uveoscleral outflow is reduced with aging, ocular hypertension, and exfoliation syndrome, unchanged in pigment dispersion syndrome accompanied by elevated IOP, and may be increased in severe glaucoma. Aqueous flow is increased in glaucomatocyclitic crisis, and unchanged in all other conditions in which IOP is increased. It is clear that each of these conditions associated with elevated IOP produces distinctive changes in aqueous humor dynamics. Tailoring a treatment to target the specific abnormality is a logical approach in the management of ocular hypertension and glaucoma.

Original languageEnglish (US)
Title of host publicationMedical Diagnosis and Therapy
PublisherElsevier Inc.
Number of pages10
ISBN (Electronic)9780702055416
ISBN (Print)9780702051937
StatePublished - 2015

ASJC Scopus subject areas

  • Medicine(all)

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