Aqueous humour dynamics and biometrics in the ageing Chinese eye

Tao Guo, Sruthi Sampathkumar, Shan Fan, Nathan Morris, Fang Wang, Carol B. Toris

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Aims This study evaluates ocular biometrics and aqueous humour dynamics (AHD) in healthy Chinese volunteers to determine how the various ocular parameters interact to maintain physiological intraocular pressure (IOP) at all ages. Methods Sixty-nine volunteers enrolled in this cross-sectional study and were categorised into young (20-30 years) and old (≥50 years) groups. Measurements included IOP, ocular biometrics and AHD. Data were analysed using mixed model with random sampling to account for both eyes from the same individual. Spearman's rank correlation with bootstrap resampling was used to find associations between parameters. Results Compared with young subjects, old subjects had significantly (p<0.05) thinner corneas (CCT; 549.7±5.7 vs 530.6±5.3 μm; mean±SEM), shallower anterior chambers (3.14±0.05 vs 2.37±0.05 mm) and slower aqueous flow (Fa; 3.0±0.1 vs 2.7±0.1 μL/min). Uveoscleral outflow slowed (Fu; 1.0±0.2 vs 0.7±0.1) but not significantly. A positive linear association between IOP and episcleral venous pressure was found (young: R 2 =0.16; old: R 2 =0.08). Negative correlation between Fa and CCT (R 2 =0.06) and positive correlation between Fa and outflow facility (R 2 =0.08) was found in old participants. Conclusions In the healthy ageing Chinese eye, IOP remains unchanged, while Fa slows, which is counterbalanced by slowing of Fu. Aqueous humour exits the eye preferentially through the trabecular route at all ages. Ageing is also associated with shallowing of the anterior chamber and thinning of the cornea. A slower Fa with lower outflow facility supports existence of autoregulatory mechanisms.

Original languageEnglish (US)
Pages (from-to)1290-1296
Number of pages7
JournalBritish Journal of Ophthalmology
Issue number9
StatePublished - Sep 2017


  • anterior chamber
  • aqueous humour
  • ciliary body
  • intraocular pressure
  • physiology

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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