ARDS: How and when does it develop?

Ruxana T. Sadikot, John W. Christman

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


The acute respiratory distress syndrome (ARDS) is characterized by dyspnea, diffuse pulmonary inflammation and injury, profound hypoxemia, and rapid development of acute respiratory failure. ARDS is precipitated by a number of direct and indirect pulmonary insults and typically appears within 24 hours of a major illness or trauma. The exudative phase, which occurs within the first 3 days, is characterized by pronounced neutrophilic inflammation. It is followed by the fibroproliferative response, which is comparable to wound healing and leads to a marked derangement of lung architecture. In this latter stage, patients usually have fever, increased interstitial markings on the chest film, diminished static lung compliance, and continued dependence on supplemental oxygen and assisted ventilation.

Original languageEnglish (US)
Pages (from-to)438-444
Number of pages7
JournalJournal of Respiratory Diseases
Issue number6
StatePublished - Jun 1999
Externally publishedYes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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