Are islet cells the gatekeepers of the pancreas?

Parviz M. Pour, Jens Standop, Surinder K. Batra

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


The pancreas is one of the body's most complex tissues composed of a mixture of endocrine and exocrine cell components. Although, islets comprise 1-2% of the pancreatic volume, there is some evidence that they control the function and the integrity of the pancreas and play the role of a gatekeeper. This review intends to highlight the importance of islet cells, not only for glucose metabolism, but also for their significant role in drug metabolism and diseases, especially in pancreatic cancer. Copyright

Original languageEnglish (US)
Pages (from-to)440-448
Number of pages9
Issue number5
StatePublished - 2002


  • Cytochrome P450
  • Glutathione S-transferase
  • N-nitrosobis(2-oxopropyl)amine

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Hepatology


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