Aromatization

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Aromatase is a cytochrome P450 enzyme which catalyzes the synthesis of estrogens from androgens. It is normally expressed in a number of cells including those found in the female ovary and male testis. Furthermore, aromatase regulates estrogen synthesis in non-reproductive tissues such as the brain, adipose tissue, and bone. Diseases associated with estrogen deficiency and excess can be attributed to altered expression and/or mutations of CYP19, which is the gene that encodes for the aromatase enzyme. Current research has also identified synthetic inhibitors of aromatase that are used to clinically treat cancers associated with estrogen excess, particularly breast cancer.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Reproduction
PublisherElsevier
Pages195-201
Number of pages7
ISBN (Electronic)9780128151457
DOIs
StatePublished - Jan 1 2018

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Keywords

  • Adipose tissue
  • Aromatase inhibitors
  • Aromatase knock-out mouse
  • Bone
  • Brain
  • Cyp19
  • Cytochrome p450
  • Endocrinology
  • Estrogen
  • Ovary
  • Reproductive behavior
  • Steroidogenesis
  • Testis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Wood, J. R., & Cupp, A. S. (2018). Aromatization. In Encyclopedia of Reproduction (pp. 195-201). Elsevier. https://doi.org/10.1016/B978-0-12-801238-3.64642-1