Arterial blood gases during cardiac arrest: markers of blood flow in a canine model

Mark G. Angelos, Daniel J. DeBehnke, James E. Leasure

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Measures of CO2 have been shown to correlate with coronary perfusion pressure and cardiac output during cardiac arrest. We evaluated arterial pH (pHa) relative to blood flow during cardiac arrest in a canine electromechanical dissociation (EMD) model of cardiac arrest using different resuscitation techniques. Following 15 min of cardiac arrest, 24 mongrel dogs received epinephrine with continued CPR or closed-chest cardiopulmonary bypass. Central arterial blood gases, end-tidal carbon dioxide (PetCO2), coronary perfusion pressure and cardiac output were measured. During CPR, prior to epinephrine or bypass, there was no correlation of pHa, PACO2 and PetCO2, with cardiac output or coronary perfusion pressure. Immediately after instituting the resuscitation techniques, both pHa and PaCO2 showed a significant correlation with cardiac output (pHa; R = -0.78, P < 0.001 and PaCO2; R = 0.87, P < 0.001) and with coronary perfusion pressure (pHa; R = -0.75, P < 0.001 and PaCO2; R = 0.75, P < 0.001). Eventual survivors (n = 15) had an early significant decrease in pHa, base excess and a significant increase in PaCO2 which was not present in non-survivors (n = 9). Neither pHa nor PaCO2 correlate with blood flow under low flow conditions of CPR. However, with effective circulatory assistance, pHa and PaCO2 reflect systemic blood flow and reperfusion washout.

Original languageEnglish (US)
Pages (from-to)101-111
Number of pages11
JournalResuscitation
Volume23
Issue number2
DOIs
StatePublished - Jan 1 1992

Keywords

  • blood gas analysis
  • cardiopulmonary arrest
  • cardiopulmonary resuscitation
  • pH

ASJC Scopus subject areas

  • Emergency Medicine
  • Emergency
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Arterial blood gases during cardiac arrest: markers of blood flow in a canine model'. Together they form a unique fingerprint.

  • Cite this