Arteriolar renin and vascular effects of angiotensin II in juxtamedullary nephrons

Daniel Casellas; Pamela K. Carmines; Madeleine Dupont; Patrick Redon; Leon C. Moore

Arteriolar renin and vascular effects of angiotensin II in juxtamedullary nephrons

Daniel Casellas, Pamela K. Carmines, Madeleine Dupont, Patrick Redon, Leon C. Moore

Research output: Contribution to journal › Article › peer-review

Abstract

The SJMNs made accessible in the in vitro juxtamedullary nephron preparation possess an arteriolar renin and Ang II distribution similar to other nephron populations; renin-rich cells prevail in the JAA. Physiological studies have documented that exogenous Ang II constricts both pre- and postglomerular vessels of SJMNs. However, Ang II predominantly increases afferent resistance along the JAA. A functional interaction between Ang II and prostaglandins is likely to occur in preglomerular vessels and deserves further assessment. An additive, functional interaction was demonstrated between Ang II and autoregulation in afferent arterioles. Calcium channel blockers interfere with Ang II-induced constriction only in preglomerular vessels of SJMNs.

Original language	English (US)
Pages (from-to)	S-60-S-64
Journal	Kidney International
Volume	38
Issue number	SUPPL. 30
State	Published - Nov 1990
Externally published	Yes

ASJC Scopus subject areas

Nephrology

Cite this

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title = "Arteriolar renin and vascular effects of angiotensin II in juxtamedullary nephrons",

abstract = "The SJMNs made accessible in the in vitro juxtamedullary nephron preparation possess an arteriolar renin and Ang II distribution similar to other nephron populations; renin-rich cells prevail in the JAA. Physiological studies have documented that exogenous Ang II constricts both pre- and postglomerular vessels of SJMNs. However, Ang II predominantly increases afferent resistance along the JAA. A functional interaction between Ang II and prostaglandins is likely to occur in preglomerular vessels and deserves further assessment. An additive, functional interaction was demonstrated between Ang II and autoregulation in afferent arterioles. Calcium channel blockers interfere with Ang II-induced constriction only in preglomerular vessels of SJMNs.",

author = "Daniel Casellas and Carmines, {Pamela K.} and Madeleine Dupont and Patrick Redon and Moore, {Leon C.}",

year = "1990",

month = nov,

language = "English (US)",

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journal = "Kidney International",

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T1 - Arteriolar renin and vascular effects of angiotensin II in juxtamedullary nephrons

AU - Casellas, Daniel

AU - Carmines, Pamela K.

AU - Dupont, Madeleine

AU - Redon, Patrick

AU - Moore, Leon C.

PY - 1990/11

Y1 - 1990/11

N2 - The SJMNs made accessible in the in vitro juxtamedullary nephron preparation possess an arteriolar renin and Ang II distribution similar to other nephron populations; renin-rich cells prevail in the JAA. Physiological studies have documented that exogenous Ang II constricts both pre- and postglomerular vessels of SJMNs. However, Ang II predominantly increases afferent resistance along the JAA. A functional interaction between Ang II and prostaglandins is likely to occur in preglomerular vessels and deserves further assessment. An additive, functional interaction was demonstrated between Ang II and autoregulation in afferent arterioles. Calcium channel blockers interfere with Ang II-induced constriction only in preglomerular vessels of SJMNs.

AB - The SJMNs made accessible in the in vitro juxtamedullary nephron preparation possess an arteriolar renin and Ang II distribution similar to other nephron populations; renin-rich cells prevail in the JAA. Physiological studies have documented that exogenous Ang II constricts both pre- and postglomerular vessels of SJMNs. However, Ang II predominantly increases afferent resistance along the JAA. A functional interaction between Ang II and prostaglandins is likely to occur in preglomerular vessels and deserves further assessment. An additive, functional interaction was demonstrated between Ang II and autoregulation in afferent arterioles. Calcium channel blockers interfere with Ang II-induced constriction only in preglomerular vessels of SJMNs.

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M3 - Article

C2 - 2259078

AN - SCOPUS:0025104161

SN - 0085-2538

VL - 38

SP - S-60-S-64

JO - Kidney International

JF - Kidney International

IS - SUPPL. 30

ER -

Arteriolar renin and vascular effects of angiotensin II in juxtamedullary nephrons

Abstract

ASJC Scopus subject areas

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