Assembly of oriented virus arrays by chemo-selective ligation methods and nanolithography techniques

Julio A. Camarero, Chin Li Cheung, Tianwei Lin, John E. Johnson, Brandon L. Weeks, Alex Noy, Jim J. De Yoreo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The present work describes our ongoing efforts towards the creation of nano-scaled ordered arrays of protein/virus covalently attached to site-specific chemical linkers patterned by different nanolithograpy techniques. We will present a new and efficient solid-phase approach for the synthesis of chemically modified long alkyl-thiols. These compounds can be used to introduce chemoselective reacting groups onto gold and silicon-based surfaces. Furthermore, these modified thiols have been used to create nanometric patterns by using different nanolithography techniques. We will show that this patterns can react chemoselectively with proteins and/or virus which have been chemically or recombinantly modified to contain complementary chemical groups at specific positions thus resulting in the oriented attachment of the protein or virus to the surface.

Original languageEnglish (US)
Title of host publication2003 Nanotechnology Conference and Trade Show - Nanotech 2003
EditorsM. Laudon, B. Romanowicz
Pages78-80
Number of pages3
StatePublished - 2003
Externally publishedYes
Event2003 Nanotechnology Conference and Trade Show - Nanotech 2003 - San Francisco, CA, United States
Duration: Feb 23 2003Feb 27 2003

Publication series

Name2003 Nanotechnology Conference and Trade Show - Nanotech 2003
Volume1

Other

Other2003 Nanotechnology Conference and Trade Show - Nanotech 2003
CountryUnited States
CitySan Francisco, CA
Period2/23/032/27/03

Keywords

  • Chemoselective Attachment
  • Cow Pea Mosaic Virus (CPMV)
  • Dip Pen Nanolithography
  • Protein Arrays

ASJC Scopus subject areas

  • Engineering(all)

Fingerprint Dive into the research topics of 'Assembly of oriented virus arrays by chemo-selective ligation methods and nanolithography techniques'. Together they form a unique fingerprint.

Cite this