TY - JOUR
T1 - Assessment of prognostic factors after primary tumor resection in metastatic colon cancer patients
T2 - A Veteran's Affairs Central Cancer Registry (VACCR) analysis, 1995-2008
AU - Gonsalves, Wilson I.
AU - Wolpert, Joseph
AU - Tashi, Tsewang
AU - Ganti, Apar K.
AU - Subbiah, Shanmuga
AU - Ternent, Charles
AU - Silberstein, Peter T.
PY - 2012/9/15
Y1 - 2012/9/15
N2 - Background Resection of the primary tumor in metastatic colon cancer may occur for palliation of bleeding or obstruction despite distant metastases. This study evaluates clinicopathologic features that serve as prognostic markers in those patients with stage IV colon cancer who undergo resection of their primary tumor. Methods Retrospective analysis of stage IV colon cancer patients who underwent surgical resection of the primary tumor from 1995 to 2008 was done via the Veteran's Affairs Central Cancer Registry. Age, Charlson co-morbidity index score, extent of metastases, sex, number of lymph nodes examined, lymph node ratio (LNR), type of surgery, use of adjuvant chemotherapy, primary tumor site, and grade were studied with respect to overall survival by using log-rank and Kaplan-Meier analysis. Results There were 2,625 patients with stage IV colon cancer who had primary tumor resection. Age at diagnosis, Charlson co-morbidity index score, lymph node ratio, and use of chemotherapy were found to be independent predictors of survival by multivariate analysis. Conclusion Clinicopathologic factors such as LNR, use of chemotherapy, age, co-morbidities, site of primary colon tumor, and number of sites of metastasis are all independent predictors of overall survival in patients who undergo primary colon tumor resection in the metastatic setting. J. Surg. Oncol. 2012; 106:486-490. © 2012 Wiley Periodicals, Inc.
AB - Background Resection of the primary tumor in metastatic colon cancer may occur for palliation of bleeding or obstruction despite distant metastases. This study evaluates clinicopathologic features that serve as prognostic markers in those patients with stage IV colon cancer who undergo resection of their primary tumor. Methods Retrospective analysis of stage IV colon cancer patients who underwent surgical resection of the primary tumor from 1995 to 2008 was done via the Veteran's Affairs Central Cancer Registry. Age, Charlson co-morbidity index score, extent of metastases, sex, number of lymph nodes examined, lymph node ratio (LNR), type of surgery, use of adjuvant chemotherapy, primary tumor site, and grade were studied with respect to overall survival by using log-rank and Kaplan-Meier analysis. Results There were 2,625 patients with stage IV colon cancer who had primary tumor resection. Age at diagnosis, Charlson co-morbidity index score, lymph node ratio, and use of chemotherapy were found to be independent predictors of survival by multivariate analysis. Conclusion Clinicopathologic factors such as LNR, use of chemotherapy, age, co-morbidities, site of primary colon tumor, and number of sites of metastasis are all independent predictors of overall survival in patients who undergo primary colon tumor resection in the metastatic setting. J. Surg. Oncol. 2012; 106:486-490. © 2012 Wiley Periodicals, Inc.
KW - lymph node ratio
KW - metastatic colon cancer
KW - surgery
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U2 - 10.1002/jso.23102
DO - 10.1002/jso.23102
M3 - Review article
C2 - 22457151
AN - SCOPUS:84865122066
SN - 0022-4790
VL - 106
SP - 486
EP - 490
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
IS - 4
ER -