TY - JOUR
T1 - Association of Household Food- and Drink-Sharing Practices with Human Herpesvirus 8 Seroconversion in a Cohort of Zambian Children
AU - Crabtree, Kay L.
AU - Wojcicki, Janet M.
AU - Minhas, Veenu
AU - Kankasa, Chipepo
AU - Mitchell, Charles
AU - Wood, Charles
N1 - Funding Information:
Funding. This work was supported by grants to C. W. from National Institute of Health Fogarty International Training Program (D43 TW01492); National Cancer Institute (CA75903); National Institute of Allergy and Infectious Disease (T32 A1060547) and the National Institute for General Medical Sciences (P30 GM103509). K.C. was a Ruth L. Kirschstein National Research Service Award T32 Fellow. Potential conflicts of interest. All authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.
Publisher Copyright:
© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
PY - 2017/11/1
Y1 - 2017/11/1
N2 - Background Human herpesvirus 8 (HHV-8) infection occurs in early childhood and is associated with human immunodeficiency virus type 1 (HIV-1) infection and risk for Kaposi sarcoma, but behaviors associated with HHV-8 transmission are not well described. Methods We enrolled and followed a prospective cohort of 270 children and their household members to investigate risk factors for HHV-8 transmission in Lusaka, Zambia. Results We report an incidence of 30.07 seroconversions per 100 child-years. Independent risk factors for HHV-8 incident infection included having a child who shared utensils with a primary caregiver (hazards ratio [HR], 2.33; 95% confidence interval [CI], 1.49-7.14), having an increasing number of HHV-8-infected household members (HR, 1.27; 95% CI, 1.09-2.79), and having ≥5 siblings/children in the household (HR, 2.24; 95% CI, 1.03-4.88). Playing with >5 children a day was protective against infection (HR, 0.54; 95% CI,.33-0.89), as was increasing child age (HR, 0.96; 95% CI,.93-.99). Conclusions This is the first study to find a temporal association between limited child feeding behaviors and risk for HHV-8 infection. Child food- and drink-sharing behaviors should be included in efforts to minimize HHV-8 transmission, and households with a large number of siblings should receive additional counseling as childhood infections occur in the home context.
AB - Background Human herpesvirus 8 (HHV-8) infection occurs in early childhood and is associated with human immunodeficiency virus type 1 (HIV-1) infection and risk for Kaposi sarcoma, but behaviors associated with HHV-8 transmission are not well described. Methods We enrolled and followed a prospective cohort of 270 children and their household members to investigate risk factors for HHV-8 transmission in Lusaka, Zambia. Results We report an incidence of 30.07 seroconversions per 100 child-years. Independent risk factors for HHV-8 incident infection included having a child who shared utensils with a primary caregiver (hazards ratio [HR], 2.33; 95% confidence interval [CI], 1.49-7.14), having an increasing number of HHV-8-infected household members (HR, 1.27; 95% CI, 1.09-2.79), and having ≥5 siblings/children in the household (HR, 2.24; 95% CI, 1.03-4.88). Playing with >5 children a day was protective against infection (HR, 0.54; 95% CI,.33-0.89), as was increasing child age (HR, 0.96; 95% CI,.93-.99). Conclusions This is the first study to find a temporal association between limited child feeding behaviors and risk for HHV-8 infection. Child food- and drink-sharing behaviors should be included in efforts to minimize HHV-8 transmission, and households with a large number of siblings should receive additional counseling as childhood infections occur in the home context.
KW - Kaposi's sarcoma-associated herpesvirus
KW - human herpesvirus 8
KW - premastication
KW - sub-Saharan Africa
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U2 - 10.1093/infdis/jix399
DO - 10.1093/infdis/jix399
M3 - Article
C2 - 28961804
AN - SCOPUS:85035065864
VL - 216
SP - 842
EP - 849
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 7
ER -