Association of inflammation-related exposures and ovarian cancer survival in a multi-site cohort study of Black women

Courtney E. Johnson; Anthony J. Alberg; Elisa V. Bandera; Lauren C. Peres; Maxwell Akonde; Lindsay J. Collin; Michele L. Cote; Theresa A. Hastert; James R. Hébert; Edward S. Peters; Bonnie Qin; Paul Terry; Ann G. Schwartz; Melissa Bondy; Michael P. Epstein; Hannah B. Mandle; Jeffrey R. Marks; Andrew B. Lawson; Joellen M. Schildkraut

doi:10.1038/s41416-023-02385-w

Association of inflammation-related exposures and ovarian cancer survival in a multi-site cohort study of Black women

Courtney E. Johnson, Anthony J. Alberg, Elisa V. Bandera, Lauren C. Peres, Maxwell Akonde, Lindsay J. Collin, Michele L. Cote, Theresa A. Hastert, James R. Hébert, Edward S. Peters, Bonnie Qin, Paul Terry, Ann G. Schwartz, Melissa Bondy, Michael P. Epstein, Hannah B. Mandle, Jeffrey R. Marks, Andrew B. Lawson, Joellen M. Schildkraut

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Abstract

Background: An association was observed between an inflammation-related risk score (IRRS) and worse overall survival (OS) among a cohort of mostly White women with invasive epithelial ovarian cancer (EOC). Herein, we evaluated the association between the IRRS and OS among Black women with EOC, a population with higher frequencies of pro-inflammatory exposures and worse survival. Methods: The analysis included 592 Black women diagnosed with EOC from the African American Cancer Epidemiology Study (AACES). Cox proportional hazards models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of the IRRS and OS, adjusting for relevant covariates. Additional inflammation-related exposures, including the energy-adjusted Dietary Inflammatory Index (E-DII^TM), were evaluated. Results: A dose–response trend was observed showing higher IRRS was associated with worse OS (per quartile HR: 1.11, 95% CI: 1.01–1.22). Adding the E-DII to the model attenuated the association of IRRS with OS, and increasing E-DII, indicating a more pro-inflammatory diet, was associated with shorter OS (per quartile HR: 1.12, 95% CI: 1.02–1.24). Scoring high on both indices was associated with shorter OS (HR: 1.54, 95% CI: 1.16–2.06). Conclusion: Higher levels of inflammation-related exposures were associated with decreased EOC OS among Black women. [Figure not available: see fulltext.].

Original language	English (US)
Pages (from-to)	1119-1125
Number of pages	7
Journal	British journal of cancer
Volume	129
Issue number	7
DOIs	https://doi.org/10.1038/s41416-023-02385-w
State	Published - Oct 19 2023

ASJC Scopus subject areas

Oncology
Cancer Research

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Johnson, C. E., Alberg, A. J., Bandera, E. V., Peres, L. C., Akonde, M., Collin, L. J., Cote, M. L., Hastert, T. A., Hébert, J. R., Peters, E. S., Qin, B., Terry, P., Schwartz, A. G., Bondy, M., Epstein, M. P., Mandle, H. B., Marks, J. R., Lawson, A. B., & Schildkraut, J. M. (2023). Association of inflammation-related exposures and ovarian cancer survival in a multi-site cohort study of Black women. British journal of cancer, 129(7), 1119-1125. https://doi.org/10.1038/s41416-023-02385-w

Johnson, CE, Alberg, AJ, Bandera, EV, Peres, LC, Akonde, M, Collin, LJ, Cote, ML, Hastert, TA, Hébert, JR, Peters, ES, Qin, B, Terry, P, Schwartz, AG, Bondy, M, Epstein, MP, Mandle, HB, Marks, JR, Lawson, AB & Schildkraut, JM 2023, 'Association of inflammation-related exposures and ovarian cancer survival in a multi-site cohort study of Black women', British journal of cancer, vol. 129, no. 7, pp. 1119-1125. https://doi.org/10.1038/s41416-023-02385-w

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title = "Association of inflammation-related exposures and ovarian cancer survival in a multi-site cohort study of Black women",

abstract = "Background: An association was observed between an inflammation-related risk score (IRRS) and worse overall survival (OS) among a cohort of mostly White women with invasive epithelial ovarian cancer (EOC). Herein, we evaluated the association between the IRRS and OS among Black women with EOC, a population with higher frequencies of pro-inflammatory exposures and worse survival. Methods: The analysis included 592 Black women diagnosed with EOC from the African American Cancer Epidemiology Study (AACES). Cox proportional hazards models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of the IRRS and OS, adjusting for relevant covariates. Additional inflammation-related exposures, including the energy-adjusted Dietary Inflammatory Index (E-DIITM), were evaluated. Results: A dose–response trend was observed showing higher IRRS was associated with worse OS (per quartile HR: 1.11, 95% CI: 1.01–1.22). Adding the E-DII to the model attenuated the association of IRRS with OS, and increasing E-DII, indicating a more pro-inflammatory diet, was associated with shorter OS (per quartile HR: 1.12, 95% CI: 1.02–1.24). Scoring high on both indices was associated with shorter OS (HR: 1.54, 95% CI: 1.16–2.06). Conclusion: Higher levels of inflammation-related exposures were associated with decreased EOC OS among Black women. [Figure not available: see fulltext.].",

author = "Johnson, {Courtney E.} and Alberg, {Anthony J.} and Bandera, {Elisa V.} and Peres, {Lauren C.} and Maxwell Akonde and Collin, {Lindsay J.} and Cote, {Michele L.} and Hastert, {Theresa A.} and H{\'e}bert, {James R.} and Peters, {Edward S.} and Bonnie Qin and Paul Terry and Schwartz, {Ann G.} and Melissa Bondy and Epstein, {Michael P.} and Mandle, {Hannah B.} and Marks, {Jeffrey R.} and Lawson, {Andrew B.} and Schildkraut, {Joellen M.}",

note = "Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive licence to Springer Nature Limited.",

year = "2023",

month = oct,

day = "19",

doi = "10.1038/s41416-023-02385-w",

language = "English (US)",

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pages = "1119--1125",

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TY - JOUR

T1 - Association of inflammation-related exposures and ovarian cancer survival in a multi-site cohort study of Black women

AU - Johnson, Courtney E.

AU - Alberg, Anthony J.

AU - Bandera, Elisa V.

AU - Peres, Lauren C.

AU - Akonde, Maxwell

AU - Collin, Lindsay J.

AU - Cote, Michele L.

AU - Hastert, Theresa A.

AU - Hébert, James R.

AU - Peters, Edward S.

AU - Qin, Bonnie

AU - Terry, Paul

AU - Schwartz, Ann G.

AU - Bondy, Melissa

AU - Epstein, Michael P.

AU - Mandle, Hannah B.

AU - Marks, Jeffrey R.

AU - Lawson, Andrew B.

AU - Schildkraut, Joellen M.

PY - 2023/10/19

Y1 - 2023/10/19

N2 - Background: An association was observed between an inflammation-related risk score (IRRS) and worse overall survival (OS) among a cohort of mostly White women with invasive epithelial ovarian cancer (EOC). Herein, we evaluated the association between the IRRS and OS among Black women with EOC, a population with higher frequencies of pro-inflammatory exposures and worse survival. Methods: The analysis included 592 Black women diagnosed with EOC from the African American Cancer Epidemiology Study (AACES). Cox proportional hazards models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of the IRRS and OS, adjusting for relevant covariates. Additional inflammation-related exposures, including the energy-adjusted Dietary Inflammatory Index (E-DIITM), were evaluated. Results: A dose–response trend was observed showing higher IRRS was associated with worse OS (per quartile HR: 1.11, 95% CI: 1.01–1.22). Adding the E-DII to the model attenuated the association of IRRS with OS, and increasing E-DII, indicating a more pro-inflammatory diet, was associated with shorter OS (per quartile HR: 1.12, 95% CI: 1.02–1.24). Scoring high on both indices was associated with shorter OS (HR: 1.54, 95% CI: 1.16–2.06). Conclusion: Higher levels of inflammation-related exposures were associated with decreased EOC OS among Black women. [Figure not available: see fulltext.].

AB - Background: An association was observed between an inflammation-related risk score (IRRS) and worse overall survival (OS) among a cohort of mostly White women with invasive epithelial ovarian cancer (EOC). Herein, we evaluated the association between the IRRS and OS among Black women with EOC, a population with higher frequencies of pro-inflammatory exposures and worse survival. Methods: The analysis included 592 Black women diagnosed with EOC from the African American Cancer Epidemiology Study (AACES). Cox proportional hazards models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of the IRRS and OS, adjusting for relevant covariates. Additional inflammation-related exposures, including the energy-adjusted Dietary Inflammatory Index (E-DIITM), were evaluated. Results: A dose–response trend was observed showing higher IRRS was associated with worse OS (per quartile HR: 1.11, 95% CI: 1.01–1.22). Adding the E-DII to the model attenuated the association of IRRS with OS, and increasing E-DII, indicating a more pro-inflammatory diet, was associated with shorter OS (per quartile HR: 1.12, 95% CI: 1.02–1.24). Scoring high on both indices was associated with shorter OS (HR: 1.54, 95% CI: 1.16–2.06). Conclusion: Higher levels of inflammation-related exposures were associated with decreased EOC OS among Black women. [Figure not available: see fulltext.].

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U2 - 10.1038/s41416-023-02385-w

DO - 10.1038/s41416-023-02385-w

M3 - Article

C2 - 37537254

AN - SCOPUS:85166647477

SN - 0007-0920

VL - 129

SP - 1119

EP - 1125

JO - British journal of cancer

JF - British journal of cancer

IS - 7

ER -

Association of inflammation-related exposures and ovarian cancer survival in a multi-site cohort study of Black women

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