TY - JOUR
T1 - Association of reduced zinc status with angiographically severe coronary atherosclerosis
T2 - A pilot study
AU - Giannoglou, George D.
AU - Konstantinou, Dimitris M.
AU - Kovatsi, Leda
AU - Chatzizisis, Yiannis S.
AU - Mikhailidis, Dimitri P.
PY - 2010/7
Y1 - 2010/7
N2 - In vitro studies attribute antiatherogenic and insulin-like properties to zinc (Zn). However, only a few conflicting clinical data exist concerning the relationship between Zn and coronary artery disease (CAD) as well as glycemic indices. We studied 72 patients without prior history of myocardial infarction or revascularization procedures, who underwent coronary angiography for evaluation of chest pain. Coronary artery disease severity was estimated using 3 angiographic scores. Zn in serum and 24-hour urine, as well as serum Zn/24-hour urine Zn ratio were determined. Serum Zn was not associated with CAD prevalence and severity. However, urinary Zn loss was significantly higher among patients with CAD and showed a positive association with CAD severity. Serum Zn/24-hour urine Zn ratio was inversely associated with CAD, as well as with diabetes mellitus prevalence, fasting glucose, and glycated hemoglobin levels. Low serum Zn/24-hour urine Zn ratio is associated with angiographically severe atherosclerosis and impaired glucose homeostasis.
AB - In vitro studies attribute antiatherogenic and insulin-like properties to zinc (Zn). However, only a few conflicting clinical data exist concerning the relationship between Zn and coronary artery disease (CAD) as well as glycemic indices. We studied 72 patients without prior history of myocardial infarction or revascularization procedures, who underwent coronary angiography for evaluation of chest pain. Coronary artery disease severity was estimated using 3 angiographic scores. Zn in serum and 24-hour urine, as well as serum Zn/24-hour urine Zn ratio were determined. Serum Zn was not associated with CAD prevalence and severity. However, urinary Zn loss was significantly higher among patients with CAD and showed a positive association with CAD severity. Serum Zn/24-hour urine Zn ratio was inversely associated with CAD, as well as with diabetes mellitus prevalence, fasting glucose, and glycated hemoglobin levels. Low serum Zn/24-hour urine Zn ratio is associated with angiographically severe atherosclerosis and impaired glucose homeostasis.
KW - coronary artery disease
KW - diabetes mellitus
KW - impaired glucose homeostasis
KW - zinc
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U2 - 10.1177/0003319710366702
DO - 10.1177/0003319710366702
M3 - Article
C2 - 20529979
AN - SCOPUS:77954037876
SN - 0003-3197
VL - 61
SP - 449
EP - 455
JO - Angiology
JF - Angiology
IS - 5
ER -