Associations between HIV infection and clinical spectrum of COVID-19: a population level analysis based on US National COVID Cohort Collaborative (N3C) data

Xueying Yang, Jing Sun, Rena C Patel, Jiajia Zhang, Siyuan Guo, Qulu Zheng, Amy L Olex, Bankole Olatosi, Sharon B Weissman, Jessica Y Islam, Christopher G Chute, Melissa Haendel, Gregory D Kirk, Xiaoming Li, Richard Moffitt, Hana Akelsrod, Keith A Crandall, Nora Francheschini, Evan French, Teresa Po-Yu ChiangG Caleb-Alexander, Kathleen M Andersen, Amanda J Vinson, Todd T Brown, Roslyn B Mannon

Research output: Contribution to journalArticlepeer-review

94 Scopus citations


BACKGROUND: Evidence of whether people living with HIV are at elevated risk of adverse COVID-19 outcomes is inconclusive. We aimed to investigate this association using the population-based National COVID Cohort Collaborative (N3C) data in the USA. METHODS: We included all adult (aged ≥18 years) COVID-19 cases with any health-care encounter from 54 clinical sites in the USA, with data being deposited into the N3C. The outcomes were COVID-19 disease severity, hospitalisation, and mortality. Encounters in the same health-care system beginning on or after January 1, 2018, were also included to provide information about pre-existing health conditions (eg, comorbidities). Logistic regression models were employed to estimate the association of HIV infection and HIV markers (CD4 cell count, viral load) with hospitalisation, mortality, and clinical severity of COVID-19 (multinomial). The models were initially adjusted for demographic characteristics, then subsequently adjusted for smoking, obesity, and a broad range of comorbidities. Interaction terms were added to assess moderation effects by demographic characteristics. FINDINGS: In the harmonised N3C data release set from Jan 1, 2020, to May 8, 2021, there were 1 436 622 adult COVID-19 cases, of these, 13 170 individuals had HIV infection. A total of 26 130 COVID-19 related deaths occurred, with 445 among people with HIV. After adjusting for all the covariates, people with HIV had higher odds of COVID-19 death (adjusted odds ratio 1·29, 95% CI 1·16-1·44) and hospitalisation (1·20, 1·15-1·26), but lower odds of mild or moderate COVID-19 (0·61, 0·59-0·64) than people without HIV. Interaction terms revealed that the elevated odds were higher among older age groups, male, Black, African American, Hispanic, or Latinx adults. A lower CD4 cell count (
Original languageEnglish (US)
Pages (from-to)e690-e700
JournalThe Lancet HIV
Issue number11
StatePublished - Nov 2021


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