TY - JOUR
T1 - Associations of Prenatal Dietary Inflammatory Potential with Childhood Respiratory Outcomes in Project Viva
AU - Hanson, Corrine
AU - Rifas-Shiman, Sheryl L.
AU - Shivappa, Nitin
AU - Wirth, Michael D.
AU - Hebert, James R.
AU - Gold, Diane
AU - Camargo, Carlos A.
AU - Sen, Sarbattama
AU - Sordillo, Joanne E.
AU - Oken, Emily
AU - Litonjua, Augusto A.
PY - 2020/3
Y1 - 2020/3
N2 - Background: Inflammation during pregnancy may be a factor in the developmental programming of asthma and wheeze in childhood. Objective: To examine associations of inflammatory potential of prenatal diet with respiratory outcomes in early childhood and midchildhood. Methods: Among 1424 mother-child pairs in Project Viva, a prebirth cohort, we examined associations of Dietary Inflammatory Index (DII®) (first trimester, second trimester, and average of first and second trimesters) scores in relation to ever asthma and wheezing in the past year (early childhood and midchildhood); current asthma and lung function (midchildhood), and wheeze trajectory during 1 to 9 years. We used multivariable linear and logistic regression modeling, adjusting for relevant confounders. Results: In a fully adjusted analysis, a more proinflammatory diet was associated with an early versus never wheeze trajectory (first- and second-trimester average fourth vs first quartile: odds ratio, 1.89; 95% CI, 1.14-3.13). A more proinflammatory diet during pregnancy also was associated with lower forced expiratory flow (forced expiratory flow at 25%-75%) in midchildhood (first- and second-trimester average fourth vs first quartile: β, −132 mL; 95% CI, −249 to −14). Results were evident for first-, but not second-, trimester DII and wheeze trajectory and midchildhood forced expiratory flow at 25% to 75%. Other child respiratory outcomes, including ever asthma, were not related to any DII measure during pregnancy. Conclusions: Proinflammatory diet during pregnancy is associated with wheeze trajectory during early childhood and decrements in small airways caliber in midchildhood, but not other respiratory outcomes in the offspring.
AB - Background: Inflammation during pregnancy may be a factor in the developmental programming of asthma and wheeze in childhood. Objective: To examine associations of inflammatory potential of prenatal diet with respiratory outcomes in early childhood and midchildhood. Methods: Among 1424 mother-child pairs in Project Viva, a prebirth cohort, we examined associations of Dietary Inflammatory Index (DII®) (first trimester, second trimester, and average of first and second trimesters) scores in relation to ever asthma and wheezing in the past year (early childhood and midchildhood); current asthma and lung function (midchildhood), and wheeze trajectory during 1 to 9 years. We used multivariable linear and logistic regression modeling, adjusting for relevant confounders. Results: In a fully adjusted analysis, a more proinflammatory diet was associated with an early versus never wheeze trajectory (first- and second-trimester average fourth vs first quartile: odds ratio, 1.89; 95% CI, 1.14-3.13). A more proinflammatory diet during pregnancy also was associated with lower forced expiratory flow (forced expiratory flow at 25%-75%) in midchildhood (first- and second-trimester average fourth vs first quartile: β, −132 mL; 95% CI, −249 to −14). Results were evident for first-, but not second-, trimester DII and wheeze trajectory and midchildhood forced expiratory flow at 25% to 75%. Other child respiratory outcomes, including ever asthma, were not related to any DII measure during pregnancy. Conclusions: Proinflammatory diet during pregnancy is associated with wheeze trajectory during early childhood and decrements in small airways caliber in midchildhood, but not other respiratory outcomes in the offspring.
KW - Asthma
KW - Childhood
KW - Diet
KW - Inflammation
KW - Lung function
KW - Pregnancy
KW - Wheeze
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U2 - 10.1016/j.jaip.2019.10.010
DO - 10.1016/j.jaip.2019.10.010
M3 - Article
C2 - 31678301
AN - SCOPUS:85075401520
VL - 8
SP - 945-952.e4
JO - Journal of Allergy and Clinical Immunology: In Practice
JF - Journal of Allergy and Clinical Immunology: In Practice
SN - 2213-2198
IS - 3
ER -