Asthma and Allergy

Lanny J. Rosenwasser, Jillian A. Poole

Research output: Chapter in Book/Report/Conference proceedingChapter


This chapter provides an overview of allergic diseases, specifically asthma. Allergic diseases are traditionally referred to as immediate or type I hypersensitivity reactions with allergen-specific IgE as an important factor. However, it is also apparent that critical cellular elements such as T lymphocytes constitute a major pathogenesis factor in the development of allergic diseases and, in particular, asthma. Dendritic cells and molecules such as the T cell receptor, major histocompatibility complex molecules, and co-stimulatory molecules are all necessary for inducing an allergic T cell inflammatory response. Clinical laboratory tools in conjunction with a thorough history and physical examination are used to diagnose properly and manage patients with allergic disorders. At present there is no in vitro test that confirms the presence of clinically relevant allergic disease. Quantitative specific IgE antibody immunoassays and Immunological assay advancements in determining cross-reactivity versus co-sensitization are explained. A comparison between skin testing and allergen specific-IgE immunoassays is presented.

Original languageEnglish (US)
Title of host publicationMeasuring Immunity
Subtitle of host publicationBasic Science and Clinical Practice
Number of pages7
ISBN (Print)9780124559004
StatePublished - Dec 30 2004
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)


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