Asymmetric Michael addition reactions using a chiral La-Na aminodiolate catalyst

N. Prabagaran, G. Sundararajan

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

(R, R)-(+)-2-[Benzyl-(2-hydroxy-2-phenylethyl)amino]-1-phenylethanol 1 is used as a chiral ligand in the synthesis of an optically active lanthanum-sodium amino diol complex LS-1. This heterobimetallic catalyst is quite effective as an asymmetric catalyst for various Michael addition reactions, 1H NMR study indicates the co-ordination of enone to the central lanthanum atom in LS-1. The reaction conditions were optimized and the adducts were obtained in high yield with moderate to high enantiomeric excess under extremely mild conditions.

Original languageEnglish (US)
Pages (from-to)1053-1058
Number of pages6
JournalTetrahedron Asymmetry
Volume13
Issue number10
DOIs
StatePublished - Jun 10 2002

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Fingerprint Dive into the research topics of 'Asymmetric Michael addition reactions using a chiral La-Na aminodiolate catalyst'. Together they form a unique fingerprint.

  • Cite this