At the center of cervical carcinogenesis: synergism between high-risk HPV and the hyperactivated YAP1

Cheng Wang, John S. Davis

Research output: Contribution to journalComment/debate

1 Scopus citations

Abstract

Human papillomavirus (HPV) is recognized as a necessary, but insufficient cause of cervical cancer. Recent in vitro and in vivo evidence from our laboratory demonstrate that hyperactivation of yes-associated protein 1 (YAP1) is sufficient to induce cervical carcinogenesis. We found that synergism between hyperactivated YAP1 and high-risk HPV is a key driver of cervical cancer initiation and progression.

Original languageEnglish (US)
Article numbere1612677
JournalMolecular and Cellular Oncology
Volume6
Issue number5
DOIs
StatePublished - 2019

Keywords

  • HPV
  • The Hippo Pathway
  • YAP1
  • cervical cancer
  • innate immunity

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research

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