Abstract
Human papillomavirus (HPV) is recognized as a necessary, but insufficient cause of cervical cancer. Recent in vitro and in vivo evidence from our laboratory demonstrate that hyperactivation of yes-associated protein 1 (YAP1) is sufficient to induce cervical carcinogenesis. We found that synergism between hyperactivated YAP1 and high-risk HPV is a key driver of cervical cancer initiation and progression.
Original language | English (US) |
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Article number | e1612677 |
Journal | Molecular and Cellular Oncology |
Volume | 6 |
Issue number | 5 |
DOIs |
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State | Published - 2019 |
Keywords
- HPV
- The Hippo Pathway
- YAP1
- cervical cancer
- innate immunity
ASJC Scopus subject areas
- Molecular Medicine
- Cancer Research