AT2 receptor signaling and sympathetic regulation

Research output: Contribution to journalReview article

50 Scopus citations

Abstract

There is a growing consensus that the balance between Angiotensin Type 1 (AT1R) and Angiotensin Type 2 (AT2R) signaling in many tissues may determine the magnitude and, in some cases the direction, of the biological response. Sympatho-excitation in cardiovascular diseases is mediated by a variety of factors and is, in part, dependent on Angiotensin II signaling in the central nervous system. Recent data have provided evidence that the AT2R can modulate sympatho-excitation in animals with hypertension and heart failure. The evidence for this concept is reviewed and a model is put forward to support the rationale that therapeutic targeting of the central AT2R may be beneficial in the setting of chronic heart failure.

Original languageEnglish (US)
Pages (from-to)124-130
Number of pages7
JournalCurrent Opinion in Pharmacology
Volume11
Issue number2
DOIs
StatePublished - Apr 2011

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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