Atomic force microscopy of RNA: Imaging and beyond

Peter M. Schön, Luda S. Shlyakhtenko, Yuri L. Lyubchenko

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Atomic force microscopy (AFM) was invented in 1986 (Binnig et al., 1986), and soon after, the first work has been done on biological samples (Drake et al., 1989; Lindsay et al., 1989). Of fundamental importance for the usability of AFM in biology was the introduction of the optical lever detection principle, which is also applicable in a liquid environment (Alexander et al., 1989; Meyer and Amer, 1988). This makes AFM a unique high-resolution imaging instrument, as biological systems can also be studied under physiological conditions without the need for labeling or staining of the samples.

Original languageEnglish (US)
Title of host publicationRNA Nanotechnology and Therapeutics
PublisherCRC Press
Pages237-261
Number of pages25
ISBN (Electronic)9781466505834
ISBN (Print)9781466505667
DOIs
StatePublished - Jan 1 2013

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Schön, P. M., Shlyakhtenko, L. S., & Lyubchenko, Y. L. (2013). Atomic force microscopy of RNA: Imaging and beyond. In RNA Nanotechnology and Therapeutics (pp. 237-261). CRC Press. https://doi.org/10.1201/b15152