Atomic force microscopy of RNA: Imaging and beyond

Peter M. Schön; Luda S. Shlyakhtenko; Yuri L. Lyubchenko

doi:10.1201/b15152

Atomic force microscopy of RNA: Imaging and beyond

Peter M. Schön, Luda S. Shlyakhtenko, Yuri L. Lyubchenko

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Atomic force microscopy (AFM) was invented in 1986 (Binnig et al., 1986), and soon after, the first work has been done on biological samples (Drake et al., 1989; Lindsay et al., 1989). Of fundamental importance for the usability of AFM in biology was the introduction of the optical lever detection principle, which is also applicable in a liquid environment (Alexander et al., 1989; Meyer and Amer, 1988). This makes AFM a unique high-resolution imaging instrument, as biological systems can also be studied under physiological conditions without the need for labeling or staining of the samples.

Original language	English (US)
Title of host publication	RNA Nanotechnology and Therapeutics
Publisher	CRC Press
Pages	237-261
Number of pages	25
ISBN (Electronic)	9781466505834
ISBN (Print)	9781466505667
DOIs	https://doi.org/10.1201/b15152
State	Published - Jan 1 2013

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

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Atomic force microscopy of RNA: Imaging and beyond

Abstract

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