Atrial natriuretic factor attenuates sympathetic neuroeffector responses in hindlimb vasculature of rabbits

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Abstract

To determine whether atrial natriuretic factor (ANF) affects vasoconstrictor responses to electrical stimulation of sympathetic nerves or intra-arterial norepinephrine (NE), changes in perfusion pressure were measured during lumbar sympathetic nerve stimulation (LSNS, 1-8 Hz), or administration of NE (50-200 ng), in an isolated constant flow-perfused hindlimb of chloralose-anesthetized rabbit before and after intra-arterial infusion of ANF (0.5 ng · mL-1 · min-1). ANF significantly attenuated responses to LSNS (relative potency, RP = 0.65) and to NE (RP = 0.47). We conclude that ANF attenuates vasoconstrictor responses to both LSNS and NE. Thus ANF alters sympathetic nervous system mediated changes in vascular resistance possibly at the neuroeffector site.

Original languageEnglish (US)
Pages (from-to)1101-1105
Number of pages5
JournalCanadian journal of physiology and pharmacology
Volume67
Issue number9
DOIs
StatePublished - 1989

Keywords

  • Atrial natriuretic factor
  • Sympathetic nerve stimulation
  • Vasculature

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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