Abstract
ANF did not prevent the formation of [3H] inositol trisphosphate in response to All but inhibited aldosterone secretion in calf adrenal glomerulosa cells. 8-bromo cGMP did not affect either inositol phosphate formation or aldosterone secretion. Changes in cytosolic Ca++ concentration induced by All, as measured by Quin 2 fluorescence, were also unaffected by ANF. No difference in adrenal cell protein phosphorylation with All or All+ANF was observed. The results suggest that ANF may inhibit aldosterone secretion through a non-guanyl cyclase linked receptor system not involving the formation of phosphoinositide-derived second messengers. Interference with protein kinase C activity cannot be ruled out.
Original language | English (US) |
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Pages (from-to) | 148-154 |
Number of pages | 7 |
Journal | Biochemical and Biophysical Research Communications |
Volume | 159 |
Issue number | 1 |
DOIs | |
State | Published - Feb 28 1989 |
Externally published | Yes |
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology