Atrial natriuretic peptide stability

Ronald Zolty, Carol Bauer, Pamila Allen, Maureen Garrity, Timothy J. Vittorio

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Objective: Atrial natriuretic peptide (ANP) is a key regulator in the homeostasis of water excretion and has emerged as an important prognostic marker for symptomatic chronic heart failure (CHF). The stability of ANP represents a crucial factor in assessing its use as a cardiac biomarker. Accordingly, we assessed the stability of ANP in blood samples collected from healthy controls and CHF subjects for a 12 month period. Methods: Blood samples from 10 healthy controls and 12 symptomatic CHF subjects with left ventricular systolic dysfunction were drawn. Determination of plasma ANP was performed by a standardized radioimmunoassay protocol. Results: The ANP levels of healthy subjects were 68.5 ± 11.6 pg/mL at baseline and 69.9 ± 17.2 pg/mL at 12 months (p = 0.71). The ANP concentrations of CHF subjects were 199.25 ± 44.8 pg/mL at baseline and 197.83 ± 47.4 pg/mL at 12 months (p = 0.70) respectively. Conclusion: ANP is a stable molecule with no evidence of degradation when stored at - 80 °C.

Original languageEnglish (US)
Pages (from-to)1255-1258
Number of pages4
JournalClinical Biochemistry
Issue number14-15
StatePublished - Oct 2008
Externally publishedYes


  • Atrial natriuretic peptide
  • Chronic heart failure
  • Stability

ASJC Scopus subject areas

  • Clinical Biochemistry

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