Attenuated renal responses to atrial natriuretic factor in streptozotocin-induced diabetic rats

K. P. Patel, P. L. Zhang

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

To determine whether the renal responses to atrial natriuretic factor (ANF) are altered in the diabetic state, the diuretic and natriuretic responses to ANF (0.25 μg·kg-1·min-1, i.v.) were measured in streptozotocin (STZ) induced diabetic (DIA) rats. Urine flow and sodium excretion were measured before and after ANF from innervated and denervated kidneys is anesthetized (Inactin 0.1 g/kg, i.p.) control and DIA rats (Sprague-Dawley rats injected with vehicle or STZ 65 mg/kg, i.p., respectively, 2 weeks prior to the experiment). Blood glucose levels were significantly elevated in the DIA group compared with the control group. ANF produced a significantly blunted diuresis and natriuresis in DIA rats compared with control rats. In addition, reducing the hyperglycemia in DIA rats by treatment with insulin (third group) reversed the blunted urine flow and sodium excretion responses to ANF. This study demonstrates that (i) there is a blunted natriuresis and diuresis to ANF in the STZ-induced DIA rats, and (ii) restoring the glucose levels to normal by insulin treatment in the DIA rats normalized the renal responses to ANF.

Original languageEnglish (US)
Pages (from-to)425-430
Number of pages6
JournalCanadian journal of physiology and pharmacology
Volume68
Issue number3
DOIs
StatePublished - 1990

Keywords

  • atrial natriuretic factor
  • diuresis
  • natriuresis
  • renal nerves

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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