Atypical motor neuron disorders

J. Americo M.Fernandes Filho, Eroboghene E. Ubogu

Research output: Chapter in Book/Report/Conference proceedingChapter


Amyotrophic lateral sclerosis is a progressive neurodegenerative disorder of motor neurons and their axons characterized by signs of upper and lower motor neuron dysfunction. When clinical features are restricted to either upper or lower motor neurons, limited to one or two body regions, or associated with non-motor manifestations, it is important to consider atypical motor neuron disorders. These are a group of disorders with varied etiologies that resemble amyotrophic lateral sclerosis in many respects but may possess distinct clinical, pathologic, and laboratory features. Some of these disorders are potentially reversible or have a better prognosis than amyotrophic lateral sclerosis. Recognizing these disorders early is necessary in order to initiate specific treatments when available and appropriately counsel patients particularly in the setting of genetic disorders.

Original languageEnglish (US)
Title of host publicationNeuromuscular Disorders in Clinical Practice
PublisherSpringer New York
Number of pages26
ISBN (Electronic)9781461465676
ISBN (Print)1461465664, 9781461465669
StatePublished - Nov 1 2014


  • Amyotrophic lateral sclerosis
  • Atypical motor neuron disease
  • Hirayama disease
  • Immune-mediated motor neuropathies
  • Kennedy disease
  • Paraneoplastic disease
  • Polyglucosan body disease
  • Post-poliomyelitis
  • Post-radiation motor neuron disease
  • multifocal motor neuropathy

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Atypical motor neuron disorders'. Together they form a unique fingerprint.

Cite this