Atypical visual processing in posttraumatic stress disorder

Christoph Mueller-Pfeiffer, Matthis Schick, Thomas Schulte-Vels, Ruth O'Gorman, Lars Michels, Chantal Martin-Soelch, James R. Blair, Michael Rufer, Ulrich Schnyder, Thomas Zeffiro, Gregor Hasler

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Background Many patients with Posttraumatic Stress Disorder (PTSD) feel overwhelmed in situations with high levels of sensory input, as in crowded situations with complex sensory characteristics. These difficulties might be related to subtle sensory processing deficits similar to those that have been found for sounds in electrophysiological studies. Method Visual processing was investigated with functional magnetic resonance imaging in trauma-exposed participants with (N = 18) and without PTSD (N = 21) employing a picture-viewing task. Results Activity observed in response to visual scenes was lower in PTSD participants 1) in the ventral stream of the visual system, including striate and extrastriate, inferior temporal, and entorhinal cortices, and 2) in dorsal and ventral attention systems (P < 0.05, FWE-corrected). These effects could not be explained by the emotional salience of the pictures. Conclusions Visual processing was substantially altered in PTSD in the ventral visual stream, a component of the visual system thought to be responsible for object property processing. Together with previous reports of subtle auditory deficits in PTSD, these findings provide strong support for potentially important sensory processing deficits, whose origins may be related to dysfunctional attention processes.

Original languageEnglish (US)
Pages (from-to)531-538
Number of pages8
JournalNeuroImage: Clinical
Volume3
DOIs
StatePublished - 2013
Externally publishedYes

Keywords

  • Dorsal stream
  • International Affective Picture System
  • Sensory perception
  • Ventral stream
  • Visual system
  • fMRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology
  • Cognitive Neuroscience

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