Auditory Brainstem Responses During Systemic Infusion of Lidocaine

Eric Javel, Daniel F. Mouney, Joann Mcgee, Edward J. Walsh

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Auditory brainstem-evoked responses (ABR) to clicks were recorded in unanesthetized restrained cats before, during, and after systemic intravenous infusion of lidocaine hydrochloride. The drug was infused continuously at varying rates. Lidocaine's major effect on ABR was to lengthen latent periods to all waveform peaks in proportion with the infusion rate. The effect on latent periods was cumulative throughout the auditory brainstem, ie, all interpeak time intervals increased. Increases in ABR latencies were not due to reductions in effective stimulus intensity because lidocaine did not reduce ABR component amplitudes or increase thresholds. The effects of the drug were reversible. The data are consistent with the notion that lidocaine, directly or indirectly, works throughout the auditory brainstem to increase axonal and synaptic conduction times.

Original languageEnglish (US)
Pages (from-to)71-76
Number of pages6
JournalArchives of Otolaryngology
Issue number2
StatePublished - Feb 1982
Externally publishedYes

ASJC Scopus subject areas

  • Otorhinolaryngology


Dive into the research topics of 'Auditory Brainstem Responses During Systemic Infusion of Lidocaine'. Together they form a unique fingerprint.

Cite this