Aureobasidium pullulans var. melanigenum fungemia in a pediatric patient

Kileen L. Mershon-Shier; Jaime G. Deville; Shirley Delair; Annette W. Fothergill; Brian Wickes; G. Sybren De Hoog; Deanna A. Sutton; Michael A. Lewinski

doi:10.3109/13693786.2010.490925

Aureobasidium pullulans var. melanigenum fungemia in a pediatric patient

Kileen L. Mershon-Shier, Jaime G. Deville, Shirley Delair, Annette W. Fothergill, Brian Wickes, G. Sybren De Hoog, Deanna A. Sutton, Michael A. Lewinski

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

This report describes a chronically ill child who presented with high fever and was diagnosed with catheter-related sepsis. Aureobasidium pullulans variety melanigenum, a dematiaceous fungus that rarely causes opportunistic infections, was recovered from multiple blood cultures. Antifungal susceptibilities were performed and the minimum inhibitory concentration (MIC) for fluconazole was 64 mg/l, suggestive of fluconazole resistance. The patient made a full recovery after removal of the catheter line and treatment with liposomal amphotericin B. This is the first case report of an elevated in vitro fluconazole MIC of an A. pullulans isolate and only the third case of successful treatment of A. pullulans fungemia.

Original language	English (US)
Pages (from-to)	80-83
Number of pages	4
Journal	Medical Mycology
Volume	49
Issue number	1
DOIs	https://doi.org/10.3109/13693786.2010.490925
State	Published - Jan 2010
Externally published	Yes

Keywords

Aureobasidium
Fluconazole
Fungemia

ASJC Scopus subject areas

Infectious Diseases

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10.3109/13693786.2010.490925

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title = "Aureobasidium pullulans var. melanigenum fungemia in a pediatric patient",

abstract = "This report describes a chronically ill child who presented with high fever and was diagnosed with catheter-related sepsis. Aureobasidium pullulans variety melanigenum, a dematiaceous fungus that rarely causes opportunistic infections, was recovered from multiple blood cultures. Antifungal susceptibilities were performed and the minimum inhibitory concentration (MIC) for fluconazole was 64 mg/l, suggestive of fluconazole resistance. The patient made a full recovery after removal of the catheter line and treatment with liposomal amphotericin B. This is the first case report of an elevated in vitro fluconazole MIC of an A. pullulans isolate and only the third case of successful treatment of A. pullulans fungemia.",

keywords = "Aureobasidium, Fluconazole, Fungemia",

author = "Mershon-Shier, {Kileen L.} and Deville, {Jaime G.} and Shirley Delair and Fothergill, {Annette W.} and Brian Wickes and {De Hoog}, {G. Sybren} and Sutton, {Deanna A.} and Lewinski, {Michael A.}",

note = "Funding Information: We would like to acknowledge the UCLA Clinical Microbiology Laboratory and Elizabeth Thompson of the Fungus Testing Laboratory for their technical services. B.L.W. was supported by grant PR054228 from the U.S. Army Medical Research and Materiel Command, Office of Congressionally Directed Medical Research Programs.",

year = "2010",

month = jan,

doi = "10.3109/13693786.2010.490925",

language = "English (US)",

volume = "49",

pages = "80--83",

journal = "Medical Mycology",

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AU - Mershon-Shier, Kileen L.

AU - Deville, Jaime G.

AU - Delair, Shirley

AU - Fothergill, Annette W.

AU - Wickes, Brian

AU - De Hoog, G. Sybren

AU - Sutton, Deanna A.

AU - Lewinski, Michael A.

N1 - Funding Information: We would like to acknowledge the UCLA Clinical Microbiology Laboratory and Elizabeth Thompson of the Fungus Testing Laboratory for their technical services. B.L.W. was supported by grant PR054228 from the U.S. Army Medical Research and Materiel Command, Office of Congressionally Directed Medical Research Programs.

PY - 2010/1

Y1 - 2010/1

N2 - This report describes a chronically ill child who presented with high fever and was diagnosed with catheter-related sepsis. Aureobasidium pullulans variety melanigenum, a dematiaceous fungus that rarely causes opportunistic infections, was recovered from multiple blood cultures. Antifungal susceptibilities were performed and the minimum inhibitory concentration (MIC) for fluconazole was 64 mg/l, suggestive of fluconazole resistance. The patient made a full recovery after removal of the catheter line and treatment with liposomal amphotericin B. This is the first case report of an elevated in vitro fluconazole MIC of an A. pullulans isolate and only the third case of successful treatment of A. pullulans fungemia.

AB - This report describes a chronically ill child who presented with high fever and was diagnosed with catheter-related sepsis. Aureobasidium pullulans variety melanigenum, a dematiaceous fungus that rarely causes opportunistic infections, was recovered from multiple blood cultures. Antifungal susceptibilities were performed and the minimum inhibitory concentration (MIC) for fluconazole was 64 mg/l, suggestive of fluconazole resistance. The patient made a full recovery after removal of the catheter line and treatment with liposomal amphotericin B. This is the first case report of an elevated in vitro fluconazole MIC of an A. pullulans isolate and only the third case of successful treatment of A. pullulans fungemia.

KW - Aureobasidium

KW - Fluconazole

KW - Fungemia

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Aureobasidium pullulans var. melanigenum fungemia in a pediatric patient

Abstract

Keywords

ASJC Scopus subject areas

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