Autoimmune neutropenia in adults

Mojtaba Akhtari, Brian Curtis, Edmund K. Waller

Research output: Contribution to journalReview articlepeer-review

80 Scopus citations


Autoimmune neutropenias (AIN) in adults are a heterogeneous group of diseases with clinical manifestations varying from being asymptomatic to having infectious complications with considerable morbidity and mortality. They are characterized by autoantibodies directed against neutrophils, resulting in destruction of neutrophils. AIN can be divided into two forms. In primary AIN, neutropenia is usually the sole hematologic abnormality and it is more common in children. Secondary AIN, which is more prevalent in adults, is associated with underlying autoimmune diseases, malignancies, infections, particularly viral, neurological diseases or drug exposure. This article is an overview of these conditions with emphasis on secondary AIN; it also discusses the available serological methods for antibody detection and recent therapeutic developments including colony stimulating factors, rituximab and Campath-1H.

Original languageEnglish (US)
Pages (from-to)62-66
Number of pages5
JournalAutoimmunity Reviews
Issue number1
StatePublished - Sep 2009
Externally publishedYes


  • Autoimmunity
  • G-CSF
  • Neutropenia

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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