Autoimmune neutropenia (AIN), characterized by an absolute neutrophil count below 1500 cells/mL in the presence of autoantibodies directed against neutrophil antigens, can be secondary to a variety of underlying diseases, such as connective tissue diseases, infections, and malignancies. However, it has not been reported in association with multiple myeloma (MM). We report a case of AIN in a patient with MM who also had a population of small lymphocytes with T-cell receptor gamma chain gene rearrangements. We also review other autoimmune manifestations of MM, the role of T-cell receptor gene rearrangement in AIN, and the implications of AIN in the management of MM. AIN can develop as a consequence of MM, and it is likely underdiagnosed because of the diagnostic difficulties. AIN can increase the risk of recurrent or serious infections in patients undergoing chemotherapy.
- Anti-neutrophil antibody
- T-cell receptor gene rearrangement
ASJC Scopus subject areas
- Cancer Research