TY - JOUR
T1 - Autoimmunity in picornavirus infections
AU - Massilamany, Chandirasegaran
AU - Koenig, Andreas
AU - Reddy, Jay
AU - Huber, Sally
AU - Buskiewicz, Iwona
N1 - Funding Information:
This work was supported by the National Institutes of Health ( HL114669 to JR and HL108371 to SAH and IB) and in part from a grant from the Lupus Research Institute, Inc. , the National Center for Research Resources ( 5P20RR021905 ), and the National Institute of General Medical Sciences ( 8P20 GM103496 ) from the National Institutes of Health (to IB). CM is a recipient of a postdoctoral research fellowship grant from the Myocarditis Foundation (New Jersey).
Publisher Copyright:
© 2015 Elsevier B.V.
PY - 2016/2
Y1 - 2016/2
N2 - Enteroviruses are small, non-enveloped, positive-sense single-strand RNA viruses, and are ubiquitously found throughout the world. These viruses usually cause asymptomatic or mild febrile illnesses, but have a propensity to induce severe diseases including type 1 diabetes and pancreatitis, paralysis and neuroinflammatory disease, myocarditis, or hepatitis. This pathogenicity may result from induction of autoimmunity to organ-specific antigens. While enterovirus-triggered autoimmunity can arise from multiple mechanisms including antigenic mimicry and release of sequestered antigens, the recent demonstration of T cells expressing dual T cell receptors arising as a natural consequence of Theiler's virus infection is the first demonstration of this autoimmune mechanism.
AB - Enteroviruses are small, non-enveloped, positive-sense single-strand RNA viruses, and are ubiquitously found throughout the world. These viruses usually cause asymptomatic or mild febrile illnesses, but have a propensity to induce severe diseases including type 1 diabetes and pancreatitis, paralysis and neuroinflammatory disease, myocarditis, or hepatitis. This pathogenicity may result from induction of autoimmunity to organ-specific antigens. While enterovirus-triggered autoimmunity can arise from multiple mechanisms including antigenic mimicry and release of sequestered antigens, the recent demonstration of T cells expressing dual T cell receptors arising as a natural consequence of Theiler's virus infection is the first demonstration of this autoimmune mechanism.
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U2 - 10.1016/j.coviro.2015.10.004
DO - 10.1016/j.coviro.2015.10.004
M3 - Review article
C2 - 26554915
AN - SCOPUS:84946616101
SN - 1879-6257
VL - 16
SP - 8
EP - 14
JO - Current Opinion in Virology
JF - Current Opinion in Virology
ER -