Automated continuous positive airway pressure titration for obstructive sleep apnea syndrome

Helmut Teschler, Michael Berthon-Jones, Austin B. Thompson, Antje Henkel, Jana Henry, Nikolaus Konietzko

Research output: Contribution to journalArticlepeer-review

197 Scopus citations


This study tested the effectiveness of the AutoSet(TM) self-titrating nasal continuous positive airway pressure (nCPAP) system in treating obstructive sleep apnea (OSA), and choosing a suitable pressure for subsequent conventional fixed-pressure nCPAP therapy. Twenty-one adult men with untreated OSA were studied with full polysomnography on each of four nights: diagnostic, manual and AutoSet nCPAP titration (in random order), and conventional fixed-pressure nCPAP at the pressure recommended by the AutoSet titration. Titration was satisfactorily performed in 20 of 21 subjects. Severe mask leak prevented automated titration in one subject and caused transient unnecessary increases in pressure in three subjects. In the 20 subjects, respiratory disturbance index (RDI) was 60.3 ± 5.7 events/h (mean ± SEM) on the diagnostic night. RDI was lower with manual titration (10.1 ± 3.0, p < 0.001), and lower still with AutoSet (2.8 ± 0.9, p < 0.01) and fixed pressure (2.5 ± 0.7, p = ns versus AutoSet) nCPAP. There were similar changes in the arousal index, which was 52.7 ± 4.6 events/h on the diagnostic night, 14.2 ± 2.4 with manual titration and 8.9 ± 0.9 with AutoSet titration, and 9.5 ± 1.0 on the night of conventional fixed- pressure CPAP (p < 0.001 versus diagnostic). We conclude that the AutoSet system is suitable for automated nCPAP pressure titration.

Original languageEnglish (US)
Pages (from-to)734-740
Number of pages7
JournalAmerican Journal of Respiratory and Critical Care Medicine
Issue number3 I
StatePublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine


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