Autophagy and p62 in cardiac protein quality control

Huabo Su, Xuejun Wang

Research output: Contribution to journalShort surveypeer-review

16 Scopus citations


This is an addendum to a recent report which demonstrates for the first time that autophagic flux is increased in the heart of a well-established mouse model of cardiac proteinopathy and p62 is transcriptionally upregulated in cardiomyocytes and hearts overexpressing human cardiomyopathy-linked misfolded proteins. The p62 plays a critical and protective role in aggresome formation and autophagic activation in cardiomyocytes overexpressing misfolded proteins.

Original languageEnglish (US)
Pages (from-to)1382-1383
Number of pages2
Issue number11
StatePublished - Nov 2011
Externally publishedYes


  • Autophagy
  • Cardiomyocytes
  • Desmin-related cardiomyopathy
  • Protein aggregation
  • p62

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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