Abstract
This is an addendum to a recent report which demonstrates for the first time that autophagic flux is increased in the heart of a well-established mouse model of cardiac proteinopathy and p62 is transcriptionally upregulated in cardiomyocytes and hearts overexpressing human cardiomyopathy-linked misfolded proteins. The p62 plays a critical and protective role in aggresome formation and autophagic activation in cardiomyocytes overexpressing misfolded proteins.
Original language | English (US) |
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Pages (from-to) | 1382-1383 |
Number of pages | 2 |
Journal | Autophagy |
Volume | 7 |
Issue number | 11 |
DOIs | |
State | Published - Nov 2011 |
Externally published | Yes |
Keywords
- Autophagy
- Cardiomyocytes
- Desmin-related cardiomyopathy
- Protein aggregation
- p62
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology