Autophagy and proteotoxicity in cardiomyocytes

J. Scott Pattison, Jeffrey Robbins

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Increasing evidence suggests that misfolded proteins and intracellular aggregates contribute to cardiac disease and heart failure. We wished to determine if autophagic induction by Atg7 is sufficient to reduce misfolded protein and aggregate content in protein misfolding-stressed cardiomyocytes. We used loss- and gain-of-function approaches in cultured cardiomyocytes to determine the effects of ATG7 knockdown and Atg7 overexpression in protein conformation-based toxicity induced by expression of a mutant aB crystallin (CryABR120G) known to cause human heart disease. We show that Atg7 induces basal autophagy and rescues the CryAB accumulation of misfolded proteins and aggregates in cardiomyocytes.

Original languageEnglish (US)
Pages (from-to)1259-1260
Number of pages2
Issue number10
StatePublished - Oct 2011
Externally publishedYes


  • Autophagy
  • Cardiomyopathy
  • Cell death
  • Heart
  • Protein misfolding

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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