Autophagy in filamentous fungi

Judith K. Pollack; Steven D. Harris; Mark R. Marten

doi:10.1016/j.fgb.2008.10.010

Autophagy in filamentous fungi

Judith K. Pollack, Steven D. Harris, Mark R. Marten

Plant Pathology

Research output: Contribution to journal › Review article › peer-review

143 Scopus citations

Abstract

Autophagy is a ubiquitous, non-selective degradation process in eukaryotic cells that is conserved from yeast to man. Autophagy research has increased significantly in the last ten years, as autophagy has been connected with cancer, neurodegenerative disease and various human developmental processes. Autophagy also appears to play an important role in filamentous fungi, impacting growth, morphology and development. In this review, an autophagy model developed for the yeast Saccharomyces cerevisiae is used as an intellectual framework to discuss autophagy in filamentous fungi. Studies imply that, similar to yeast, fungal autophagy is characterized by the presence of autophagosomes and controlled by Tor kinase. In addition, fungal autophagy is apparently involved in protection against cell death and has significant effects on cellular growth and development. However, the only putative autophagy proteins characterized in filamentous fungi are Atg1 and Atg8. We discuss various strategies used to study and monitor fungal autophagy as well as the possible relationship between autophagy, physiology, and morphological development.

Original language	English (US)
Pages (from-to)	1-8
Number of pages	8
Journal	Fungal Genetics and Biology
Volume	46
Issue number	1
DOIs	https://doi.org/10.1016/j.fgb.2008.10.010
State	Published - Jan 2009

Keywords

Atg1
Atg8
Autophagy
Cell death
Development
Filamentous fungi
Morphology
Tor

ASJC Scopus subject areas

Microbiology
Genetics

Access to Document

10.1016/j.fgb.2008.10.010

Cite this

@article{beb7cb0f1695494e80c5869f152b654e,

title = "Autophagy in filamentous fungi",

abstract = "Autophagy is a ubiquitous, non-selective degradation process in eukaryotic cells that is conserved from yeast to man. Autophagy research has increased significantly in the last ten years, as autophagy has been connected with cancer, neurodegenerative disease and various human developmental processes. Autophagy also appears to play an important role in filamentous fungi, impacting growth, morphology and development. In this review, an autophagy model developed for the yeast Saccharomyces cerevisiae is used as an intellectual framework to discuss autophagy in filamentous fungi. Studies imply that, similar to yeast, fungal autophagy is characterized by the presence of autophagosomes and controlled by Tor kinase. In addition, fungal autophagy is apparently involved in protection against cell death and has significant effects on cellular growth and development. However, the only putative autophagy proteins characterized in filamentous fungi are Atg1 and Atg8. We discuss various strategies used to study and monitor fungal autophagy as well as the possible relationship between autophagy, physiology, and morphological development.",

keywords = "Atg1, Atg8, Autophagy, Cell death, Development, Filamentous fungi, Morphology, Tor",

author = "Pollack, {Judith K.} and Harris, {Steven D.} and Marten, {Mark R.}",

note = "Funding Information: To the best of our knowledge, the studies reviewed here represent the totality of filamentous fungal autophagy studies currently available in the literature. We sincerely apologize to authors of appropriate studies that may have been inadvertently omitted. This material is based upon work supported by the National Science Foundation under grant No. 0519080. Any opinions, findings, conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation.",

year = "2009",

month = jan,

doi = "10.1016/j.fgb.2008.10.010",

language = "English (US)",

volume = "46",

pages = "1--8",

journal = "Fungal Genetics and Biology",

issn = "1087-1845",

publisher = "Academic Press Inc.",

number = "1",

}

TY - JOUR

T1 - Autophagy in filamentous fungi

AU - Pollack, Judith K.

AU - Harris, Steven D.

AU - Marten, Mark R.

N1 - Funding Information: To the best of our knowledge, the studies reviewed here represent the totality of filamentous fungal autophagy studies currently available in the literature. We sincerely apologize to authors of appropriate studies that may have been inadvertently omitted. This material is based upon work supported by the National Science Foundation under grant No. 0519080. Any opinions, findings, conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation.

PY - 2009/1

Y1 - 2009/1

N2 - Autophagy is a ubiquitous, non-selective degradation process in eukaryotic cells that is conserved from yeast to man. Autophagy research has increased significantly in the last ten years, as autophagy has been connected with cancer, neurodegenerative disease and various human developmental processes. Autophagy also appears to play an important role in filamentous fungi, impacting growth, morphology and development. In this review, an autophagy model developed for the yeast Saccharomyces cerevisiae is used as an intellectual framework to discuss autophagy in filamentous fungi. Studies imply that, similar to yeast, fungal autophagy is characterized by the presence of autophagosomes and controlled by Tor kinase. In addition, fungal autophagy is apparently involved in protection against cell death and has significant effects on cellular growth and development. However, the only putative autophagy proteins characterized in filamentous fungi are Atg1 and Atg8. We discuss various strategies used to study and monitor fungal autophagy as well as the possible relationship between autophagy, physiology, and morphological development.

AB - Autophagy is a ubiquitous, non-selective degradation process in eukaryotic cells that is conserved from yeast to man. Autophagy research has increased significantly in the last ten years, as autophagy has been connected with cancer, neurodegenerative disease and various human developmental processes. Autophagy also appears to play an important role in filamentous fungi, impacting growth, morphology and development. In this review, an autophagy model developed for the yeast Saccharomyces cerevisiae is used as an intellectual framework to discuss autophagy in filamentous fungi. Studies imply that, similar to yeast, fungal autophagy is characterized by the presence of autophagosomes and controlled by Tor kinase. In addition, fungal autophagy is apparently involved in protection against cell death and has significant effects on cellular growth and development. However, the only putative autophagy proteins characterized in filamentous fungi are Atg1 and Atg8. We discuss various strategies used to study and monitor fungal autophagy as well as the possible relationship between autophagy, physiology, and morphological development.

KW - Atg1

KW - Atg8

KW - Autophagy

KW - Cell death

KW - Development

KW - Filamentous fungi

KW - Morphology

KW - Tor

UR - http://www.scopus.com/inward/record.url?scp=57649227755&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=57649227755&partnerID=8YFLogxK

U2 - 10.1016/j.fgb.2008.10.010

DO - 10.1016/j.fgb.2008.10.010

M3 - Review article

C2 - 19010432

AN - SCOPUS:57649227755

SN - 1087-1845

VL - 46

SP - 1

EP - 8

JO - Fungal Genetics and Biology

JF - Fungal Genetics and Biology

IS - 1

ER -

Autophagy in filamentous fungi

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this