Autophagy in filamentous fungi

Judith K. Pollack, Steven D. Harris, Mark R. Marten

Research output: Contribution to journalReview article

95 Scopus citations

Abstract

Autophagy is a ubiquitous, non-selective degradation process in eukaryotic cells that is conserved from yeast to man. Autophagy research has increased significantly in the last ten years, as autophagy has been connected with cancer, neurodegenerative disease and various human developmental processes. Autophagy also appears to play an important role in filamentous fungi, impacting growth, morphology and development. In this review, an autophagy model developed for the yeast Saccharomyces cerevisiae is used as an intellectual framework to discuss autophagy in filamentous fungi. Studies imply that, similar to yeast, fungal autophagy is characterized by the presence of autophagosomes and controlled by Tor kinase. In addition, fungal autophagy is apparently involved in protection against cell death and has significant effects on cellular growth and development. However, the only putative autophagy proteins characterized in filamentous fungi are Atg1 and Atg8. We discuss various strategies used to study and monitor fungal autophagy as well as the possible relationship between autophagy, physiology, and morphological development.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalFungal Genetics and Biology
Volume46
Issue number1
DOIs
StatePublished - Jan 2009

Keywords

  • Atg1
  • Atg8
  • Autophagy
  • Cell death
  • Development
  • Filamentous fungi
  • Morphology
  • Tor

ASJC Scopus subject areas

  • Microbiology
  • Genetics

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  • Cite this

    Pollack, J. K., Harris, S. D., & Marten, M. R. (2009). Autophagy in filamentous fungi. Fungal Genetics and Biology, 46(1), 1-8. https://doi.org/10.1016/j.fgb.2008.10.010