Auxiliary subunits: Essential components of the voltage-gated calcium channel complex

Jyothi Arikkath; Kevin P. Campbell

doi:10.1016/S0959-4388(03)00066-7

Auxiliary subunits: Essential components of the voltage-gated calcium channel complex

Jyothi Arikkath, Kevin P. Campbell

Research output: Contribution to journal › Review article › peer-review

442 Scopus citations

Abstract

Voltage-gated calcium channels are important mediators of several physiological processes, including neuronal excitability and muscle contraction. At the molecular level, the channels are composed of four subunits - the pore forming α₁ subunit and the auxiliary α₂δ, β and γ subunits. The auxiliary subunits modulate the trafficking and the biophysical properties of the α₁ subunit. In the past several years there has been an acceleration of our understanding of the auxiliary subunits, primarily because of their molecular characterization and the availability of spontaneous and targeted mouse mutants. These studies have revealed the crucial role of the subunits in the functional effects that are mediated by voltage-gated calcium channels.

Original language	English (US)
Pages (from-to)	298-307
Number of pages	10
Journal	Current Opinion in Neurobiology
Volume	13
Issue number	3
DOIs	https://doi.org/10.1016/S0959-4388(03)00066-7
State	Published - Jun 2003
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience

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10.1016/S0959-4388(03)00066-7

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title = "Auxiliary subunits: Essential components of the voltage-gated calcium channel complex",

abstract = "Voltage-gated calcium channels are important mediators of several physiological processes, including neuronal excitability and muscle contraction. At the molecular level, the channels are composed of four subunits - the pore forming α1 subunit and the auxiliary α2δ, β and γ subunits. The auxiliary subunits modulate the trafficking and the biophysical properties of the α1 subunit. In the past several years there has been an acceleration of our understanding of the auxiliary subunits, primarily because of their molecular characterization and the availability of spontaneous and targeted mouse mutants. These studies have revealed the crucial role of the subunits in the functional effects that are mediated by voltage-gated calcium channels.",

author = "Jyothi Arikkath and Campbell, {Kevin P.}",

note = "Funding Information: We would like to thank all the members of the Campbell laboratory for critical reading of the manuscript and discussion. We would also like to thank Christina Gurnett and Ricardo Felix for comments and discussion. J Arikkath was partly funded by a predoctoral fellowship from the American Heart Association. KP Campbell is an investigator of the Howard Hughes Medical Institute.",

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AU - Arikkath, Jyothi

AU - Campbell, Kevin P.

N1 - Funding Information: We would like to thank all the members of the Campbell laboratory for critical reading of the manuscript and discussion. We would also like to thank Christina Gurnett and Ricardo Felix for comments and discussion. J Arikkath was partly funded by a predoctoral fellowship from the American Heart Association. KP Campbell is an investigator of the Howard Hughes Medical Institute.

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N2 - Voltage-gated calcium channels are important mediators of several physiological processes, including neuronal excitability and muscle contraction. At the molecular level, the channels are composed of four subunits - the pore forming α1 subunit and the auxiliary α2δ, β and γ subunits. The auxiliary subunits modulate the trafficking and the biophysical properties of the α1 subunit. In the past several years there has been an acceleration of our understanding of the auxiliary subunits, primarily because of their molecular characterization and the availability of spontaneous and targeted mouse mutants. These studies have revealed the crucial role of the subunits in the functional effects that are mediated by voltage-gated calcium channels.

AB - Voltage-gated calcium channels are important mediators of several physiological processes, including neuronal excitability and muscle contraction. At the molecular level, the channels are composed of four subunits - the pore forming α1 subunit and the auxiliary α2δ, β and γ subunits. The auxiliary subunits modulate the trafficking and the biophysical properties of the α1 subunit. In the past several years there has been an acceleration of our understanding of the auxiliary subunits, primarily because of their molecular characterization and the availability of spontaneous and targeted mouse mutants. These studies have revealed the crucial role of the subunits in the functional effects that are mediated by voltage-gated calcium channels.

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Auxiliary subunits: Essential components of the voltage-gated calcium channel complex

Abstract

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