TY - JOUR
T1 - Auxiliary subunits
T2 - Essential components of the voltage-gated calcium channel complex
AU - Arikkath, Jyothi
AU - Campbell, Kevin P.
PY - 2003/6
Y1 - 2003/6
N2 - Voltage-gated calcium channels are important mediators of several physiological processes, including neuronal excitability and muscle contraction. At the molecular level, the channels are composed of four subunits - the pore forming α1 subunit and the auxiliary α2δ, β and γ subunits. The auxiliary subunits modulate the trafficking and the biophysical properties of the α1 subunit. In the past several years there has been an acceleration of our understanding of the auxiliary subunits, primarily because of their molecular characterization and the availability of spontaneous and targeted mouse mutants. These studies have revealed the crucial role of the subunits in the functional effects that are mediated by voltage-gated calcium channels.
AB - Voltage-gated calcium channels are important mediators of several physiological processes, including neuronal excitability and muscle contraction. At the molecular level, the channels are composed of four subunits - the pore forming α1 subunit and the auxiliary α2δ, β and γ subunits. The auxiliary subunits modulate the trafficking and the biophysical properties of the α1 subunit. In the past several years there has been an acceleration of our understanding of the auxiliary subunits, primarily because of their molecular characterization and the availability of spontaneous and targeted mouse mutants. These studies have revealed the crucial role of the subunits in the functional effects that are mediated by voltage-gated calcium channels.
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U2 - 10.1016/S0959-4388(03)00066-7
DO - 10.1016/S0959-4388(03)00066-7
M3 - Review article
C2 - 12850214
AN - SCOPUS:0038045158
VL - 13
SP - 298
EP - 307
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
SN - 0959-4388
IS - 3
ER -