@article{7422859e3a6f4e188398825cd8576cba,
title = "Baricitinib Treatment of Coronavirus Disease 2019 Is Associated With a Reduction in Secondary Infections",
abstract = "We performed a secondary analysis of the National Institutes of Health-sponsored Adaptive COVID-19 Treatment Trial (ACTT-2) randomized controlled trial and found that baricitinib was associated with a 50% reduction in secondary infections after controlling for baseline and postrandomization patient characteristics. This finding provides a novel mechanism of benefit for baricitinib and supports the safety profile of this immunomodulator for the treatment of coronavirus disease 2019.",
keywords = "COVID-19, baricitinib, secondary infections",
author = "Sweeney, {Daniel A.} and Bonifride Tuyishimire and Neera Ahuja and Beigel, {John H.} and Tatiana Beresnev and Cantos, {Valeria D.} and Castro, {Jose G.} and Cohen, {Stuart H.} and Kaitlyn Cross and Dodd, {Lori E.} and Nathan Erdmann and Monica Fung and Varduhi Ghazaryan and George, {Sarah L.} and Grimes, {Kevin A.} and Hynes, {Noreen A.} and Julian, {Kathleen G.} and Sheetal Kandiah and Kim, {Hannah Jang} and Levine, {Corri B.} and Lindholm, {David A.} and Lye, {David C.} and Maves, {Ryan C.} and Oh, {Myoung Don} and Catharine Paules and Rapaka, {Rekha R.} and Short, {Willam R.} and Tomashek, {Kay M.} and Wolfe, {Cameron R.} and Kalil, {Andre C.}",
note = "Funding Information: Acknowledgments Author contributions. B. T and K. C. had full access to the study data and take responsibility for both the fidelity of the data and the accuracy of the analysis. Concept and design: A. C. K. Analysis and interpretation of the data: All authors. Initial draft of the manuscript: D. A. S. and A. C. K. Editing and revisions of the manuscript: All authors. Disclaimer. The views expressed herein are those of the authors and do not reflect the official policy or position of Brooke Army Medical Center, Uniformed Services University of the Health Sciences (USUHS), the Department of Defense, or any agencies under the US government. Potential conflicts of interest. All authors: No reported conflicts. Publisher Copyright: {\textcopyright} 2023 The Author(s). Published by Oxford University Press on behalf of Infectious Diseases Society of America.",
year = "2023",
month = may,
day = "1",
doi = "10.1093/ofid/ofad205",
language = "English (US)",
volume = "10",
journal = "Open Forum Infectious Diseases",
issn = "2328-8957",
publisher = "Oxford University Press",
number = "5",
}