Baroreceptor reflex in heart failure.

Wei Wang, Guo Qing Zhu, Lie Gao, Wen Tan, Zhong Ming Qian

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations

Abstract

Congestive heart failure is a syndrome that is usually initiated by a reduction in pump function of the heart, i.e. a decrease in cardiac output. Initially, a reduction in cardiac output leads to unloading of baroreceptor reflex that, in turn, increases heart rate through vago-sympathetic mechanisms and total peripheral resistance via an increase in sympathetic outflow to vascular beds. In this review we are thinking on how baroreceptor reflex plays a role in the abnormal control of the circulation in heart failure. This review and our recent studies suggest that: (1) baroreceptor reflex is blunted in heart failure; (2) central angiotensin II and reactive oxygen species play an important role in blunted baroreceptor reflex; (3) cardiac sympathetic afferent stimulation and chemoreceptor reflex inhibit baroreceptor reflex; and (4) exercise training normalizes abnormal reflexes in the heart failure state.

Original languageEnglish (US)
Pages (from-to)269-281
Number of pages13
JournalSheng li xue bao : [Acta physiologica Sinica]
Volume56
Issue number3
StatePublished - Jun 25 2004

ASJC Scopus subject areas

  • Medicine(all)

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