TY - JOUR
T1 - Barrier to Autointegration Factor (BANF1)
T2 - Interwoven roles in nuclear structure, genome integrity, innate immunity, stress responses and progeria
AU - Jamin, Augusta
AU - Wiebe, Matthew S.
N1 - Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - The Barrier to Autointegration Factor (BAF or BANF1) is an abundant, highly conserved DNA binding protein. BAF is involved in multiple pathways including mitosis, nuclear assembly, viral infection, chromatin and gene regulation and the DNA damage response. BAF is also essential for early development in metazoans and relevant to human physiology; BANF1 mutations cause a progeroid syndrome, placing BAF within the laminopathy disease spectrum. This review summarizes previous knowledge about BAF in the context of recent discoveries about its protein partners, posttranslational regulation, dynamic subcellular localizations and roles in disease, innate immunity, transposable elements and genome integrity.
AB - The Barrier to Autointegration Factor (BAF or BANF1) is an abundant, highly conserved DNA binding protein. BAF is involved in multiple pathways including mitosis, nuclear assembly, viral infection, chromatin and gene regulation and the DNA damage response. BAF is also essential for early development in metazoans and relevant to human physiology; BANF1 mutations cause a progeroid syndrome, placing BAF within the laminopathy disease spectrum. This review summarizes previous knowledge about BAF in the context of recent discoveries about its protein partners, posttranslational regulation, dynamic subcellular localizations and roles in disease, innate immunity, transposable elements and genome integrity.
UR - http://www.scopus.com/inward/record.url?scp=84930947379&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84930947379&partnerID=8YFLogxK
U2 - 10.1016/j.ceb.2015.05.006
DO - 10.1016/j.ceb.2015.05.006
M3 - Review article
C2 - 26072104
AN - SCOPUS:84930947379
SN - 0955-0674
VL - 34
SP - 61
EP - 68
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
ER -