Bcl-2 mediates induction of neural differentiation

Ye Liang, Zeljka Korade Mirnics, Chaohua Yan, Karen D. Nylander, Nina Felice Schor

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Bcl-2 is an antiapoptotic protein expressed in a wide variety of cell types. We have found that overexpression of bcl-2 in PC12 neural crest tumor cells leads to increased expression of neural differentiation-associated genes and decreased expression of proliferation-related genes. Culture growth rate decreases as well. Overexpression of bcl-2 also leads to increased expression of TrkA and increased phosphorylation of signal transductants in, albeit not specific for, the TrkA-MEK-ERK pathway. Blocking of NGF-mediated signaling through TrkA prevents Bcl-2-associated expression changes in differentiation-associated genes, raising the possibility that Bcl-2 mediates induction of neural differentiation through TrkA/NGF signaling.

Original languageEnglish (US)
Pages (from-to)5515-5518
Number of pages4
JournalOncogene
Volume22
Issue number35
DOIs
StatePublished - Aug 21 2003
Externally publishedYes

Keywords

  • Bcl-2
  • DNA microarray
  • Nerve growth factor
  • Neural differentiation
  • TrkA

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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