Abstract
Bcl-2 is an antiapoptotic protein expressed in a wide variety of cell types. We have found that overexpression of bcl-2 in PC12 neural crest tumor cells leads to increased expression of neural differentiation-associated genes and decreased expression of proliferation-related genes. Culture growth rate decreases as well. Overexpression of bcl-2 also leads to increased expression of TrkA and increased phosphorylation of signal transductants in, albeit not specific for, the TrkA-MEK-ERK pathway. Blocking of NGF-mediated signaling through TrkA prevents Bcl-2-associated expression changes in differentiation-associated genes, raising the possibility that Bcl-2 mediates induction of neural differentiation through TrkA/NGF signaling.
Original language | English (US) |
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Pages (from-to) | 5515-5518 |
Number of pages | 4 |
Journal | Oncogene |
Volume | 22 |
Issue number | 35 |
DOIs | |
State | Published - Aug 21 2003 |
Externally published | Yes |
Keywords
- Bcl-2
- DNA microarray
- Nerve growth factor
- Neural differentiation
- TrkA
ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Cancer Research