Behavioural consequences of cocaine withdrawal in rats

Yiu K. Fung, Lori A. Richard

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28 Scopus citations


Abstract— This study was designed to examine the impact of cocaine withdrawal on several behavioural parameters in rats. After 1 and 3 day withdrawal from continuous cocaine administration (50 mg kg−1 for 28 days, subcutaneous infusion via osmotic minipumps), rats showed significant changes in spontaneous locomotor activity, conditioned avoidance response and increased levels of anxiety. However, cocaine withdrawal did not alter the motor co‐ordination, body weight, food and water consumption of these animals. The neurochemical effects of cocaine on central dopaminergic neuronal systems may account for locomotor deficit observed in these cocaine‐withdrawal animals. 1994 Royal Pharmaceutical Society of Great Britain

Original languageEnglish (US)
Pages (from-to)150-152
Number of pages3
JournalJournal of Pharmacy and Pharmacology
Issue number2
Publication statusPublished - Feb 1994


ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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