Benefits and opportunities of the transgenic Oncopig cancer model

Kirtan Joshi; Bhanu P. Telugu; Randall S. Prather; Jeffrey N. Bryan; Timothy J. Hoffman; Jussuf T. Kaifi; Satyanarayana Rachagani

doi:10.1016/j.trecan.2024.01.005

Benefits and opportunities of the transgenic Oncopig cancer model

Kirtan Joshi, Bhanu P. Telugu, Randall S. Prather, Jeffrey N. Bryan, Timothy J. Hoffman, Jussuf T. Kaifi, Satyanarayana Rachagani

Biochemistry & Molecular Biology

Research output: Contribution to journal › Short survey › peer-review

Abstract

Cancer remains a leading cause of morbidity and mortality, and a paradigm shift is needed to fundamentally revisit drug development efforts. Pigs share close similarities to humans and may serve as an alternative model. Recently, a transgenic ‘Oncopig’ line has been generated to induce solid tumors with organ specificity, opening the potential of Oncopigs as a platform for developing novel therapeutic regimens.

Original language	English (US)
Pages (from-to)	182-184
Number of pages	3
Journal	Trends in Cancer
Volume	10
Issue number	3
DOIs	https://doi.org/10.1016/j.trecan.2024.01.005
State	Published - Mar 2024

Keywords

Oncopig
large animal cancer model
porcine cancer model
transgenic cancer model
translational cancer research

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.trecan.2024.01.005

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title = "Benefits and opportunities of the transgenic Oncopig cancer model",

abstract = "Cancer remains a leading cause of morbidity and mortality, and a paradigm shift is needed to fundamentally revisit drug development efforts. Pigs share close similarities to humans and may serve as an alternative model. Recently, a transgenic {\textquoteleft}Oncopig{\textquoteright} line has been generated to induce solid tumors with organ specificity, opening the potential of Oncopigs as a platform for developing novel therapeutic regimens.",

keywords = "Oncopig, large animal cancer model, porcine cancer model, transgenic cancer model, translational cancer research",

author = "Kirtan Joshi and Telugu, {Bhanu P.} and Prather, {Randall S.} and Bryan, {Jeffrey N.} and Hoffman, {Timothy J.} and Kaifi, {Jussuf T.} and Satyanarayana Rachagani",

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year = "2024",

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doi = "10.1016/j.trecan.2024.01.005",

language = "English (US)",

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T1 - Benefits and opportunities of the transgenic Oncopig cancer model

AU - Joshi, Kirtan

AU - Telugu, Bhanu P.

AU - Prather, Randall S.

AU - Bryan, Jeffrey N.

AU - Hoffman, Timothy J.

AU - Kaifi, Jussuf T.

AU - Rachagani, Satyanarayana

PY - 2024/3

Y1 - 2024/3

N2 - Cancer remains a leading cause of morbidity and mortality, and a paradigm shift is needed to fundamentally revisit drug development efforts. Pigs share close similarities to humans and may serve as an alternative model. Recently, a transgenic ‘Oncopig’ line has been generated to induce solid tumors with organ specificity, opening the potential of Oncopigs as a platform for developing novel therapeutic regimens.

AB - Cancer remains a leading cause of morbidity and mortality, and a paradigm shift is needed to fundamentally revisit drug development efforts. Pigs share close similarities to humans and may serve as an alternative model. Recently, a transgenic ‘Oncopig’ line has been generated to induce solid tumors with organ specificity, opening the potential of Oncopigs as a platform for developing novel therapeutic regimens.

KW - Oncopig

KW - large animal cancer model

KW - porcine cancer model

KW - transgenic cancer model

KW - translational cancer research

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UR - http://www.scopus.com/inward/citedby.url?scp=85184177127&partnerID=8YFLogxK

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DO - 10.1016/j.trecan.2024.01.005

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SN - 2405-8033

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EP - 184

JO - Trends in Cancer

JF - Trends in Cancer

IS - 3

ER -

Benefits and opportunities of the transgenic Oncopig cancer model

Abstract

Keywords

ASJC Scopus subject areas

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