Benign and Malignant Granular Cell Tumor of the Hypopharynx: Two Faces of a Rare Entity

Elizabeth Jo Bradford Bell, Giovana R. Thomas, Jason Leibowitz, Jaylou M. Velez Torres

Research output: Contribution to journalArticle

Abstract

Granular cell tumors (GCT) are rare soft tissue tumors that involve the head and neck in 50% of patients. Two distinct variants of GCT, one benign (bGCT) and the other malignant (mGCT), involving the hypopharynx, a subsite of the larynx, are presented here. The clinical presentations, radiographic features, pathologic diagnosis in these two variants of GCT are discussed. The mGCT was diagnosed only after complete tumor excision. This report highlights the importance of complete excision of the tumor mass, as diagnosis of mGCT can be exceedingly difficult to make on a small biopsy specimen. Therefore, complete excision is recommended for definitive diagnosis and treatment of GCTs.

Original languageEnglish (US)
JournalHead and Neck Pathology
DOIs
StateAccepted/In press - 2020

Keywords

  • Atypia
  • Benign
  • Granular cell tumor
  • Hypopharynx
  • Malignant
  • Metastasis
  • Necrosis
  • Surgery

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Otorhinolaryngology
  • Oncology

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