TY - JOUR
T1 - Benign versus malignant hepatic nodules
T2 - MR imaging findings with pathologic correlation
AU - Hussain, Shahid M.
AU - Zondervan, Pieter E.
AU - Ijzermans, Jan N.M.
AU - Schalm, Solko W.
AU - De Man, Rob A.
AU - Krestin, Gabriel P.
PY - 2002
Y1 - 2002
N2 - According to the currently used nomenclature, there are only two types of hepatocellular nodular lesions: regenerative lesions and dysplastic or neoplastic lesions. Regenerative nodules include monoacinar regenerative nodules, multiacinar regenerative nodules, cirrhotic nodules, segmental or lobar hyperplasia, and focal nodular hyperplasia. Dysplastic or neoplastic nodules include hepatocellular adenoma, dysplastic foci, dysplastic nodules, and hepatocellular carcinoma (HCC). Many of these types of hepatic nodules play a role in the de novo and stepwise carcinogenesis of HCC, which comprises the following steps: regenerative nodule, low-grade dysplastic nodule, high-grade dysplastic nodule, small HCC, and large HCC. State-of-the-art magnetic resonance (MR) imaging facilitates detection and characterization in most cases of hepatic nodules. State-of-the-art MR imaging includes single-shot fast spin-echo imaging, in-phase and opposed-phase T1-weighted gradient-echo imaging, T2-weighted fast spin-echo imaging with fat saturation, and two-dimensional or three-dimensional dynamic multiphase contrast material-enhanced imaging.
AB - According to the currently used nomenclature, there are only two types of hepatocellular nodular lesions: regenerative lesions and dysplastic or neoplastic lesions. Regenerative nodules include monoacinar regenerative nodules, multiacinar regenerative nodules, cirrhotic nodules, segmental or lobar hyperplasia, and focal nodular hyperplasia. Dysplastic or neoplastic nodules include hepatocellular adenoma, dysplastic foci, dysplastic nodules, and hepatocellular carcinoma (HCC). Many of these types of hepatic nodules play a role in the de novo and stepwise carcinogenesis of HCC, which comprises the following steps: regenerative nodule, low-grade dysplastic nodule, high-grade dysplastic nodule, small HCC, and large HCC. State-of-the-art magnetic resonance (MR) imaging facilitates detection and characterization in most cases of hepatic nodules. State-of-the-art MR imaging includes single-shot fast spin-echo imaging, in-phase and opposed-phase T1-weighted gradient-echo imaging, T2-weighted fast spin-echo imaging with fat saturation, and two-dimensional or three-dimensional dynamic multiphase contrast material-enhanced imaging.
KW - Liver neoplasms, diagnosis, 761.319, 761.32
KW - Liver, MR, 761.121411, 761.121412, 761.12143 liver, nodules, 761.319, 761.32
KW - Liver, focal nodular hyperplasia, 761.3198
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U2 - 10.1148/radiographics.22.5.g02se061023
DO - 10.1148/radiographics.22.5.g02se061023
M3 - Article
C2 - 12235331
AN - SCOPUS:0036728098
VL - 22
SP - 1023
EP - 1036
JO - Radiographics
JF - Radiographics
SN - 0271-5333
IS - 5
ER -