Berberine derivatives as antileishmanial drugs

J. L. Vennerstrom, J. K. Lovelace, V. B. Waits, W. L. Hanson, D. L. Klayman

Research output: Contribution to journalArticlepeer-review

92 Scopus citations

Abstract

Berberine, a quaternary alkaloid, and several of its derivatives were tested for efficacy against Leishmania donovani and Leishmania braziliensis panamensis in golden hamsters. Tetrahydroberberine was less toxic and more potent than berberine against L. donovani but was not potent as meglumine antimonate (Glucantime), a standard drug for the treatment of leishmaniasis. Only berberine and 8-cyanodihydroberberine showed significant activity (> 50% suppression of lesion size) against L. braziliensis panamensis.

Original languageEnglish (US)
Pages (from-to)918-921
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume34
Issue number5
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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