Abstract
Berberine, a quaternary alkaloid, and several of its derivatives were tested for efficacy against Leishmania donovani and Leishmania braziliensis panamensis in golden hamsters. Tetrahydroberberine was less toxic and more potent than berberine against L. donovani but was not potent as meglumine antimonate (Glucantime), a standard drug for the treatment of leishmaniasis. Only berberine and 8-cyanodihydroberberine showed significant activity (> 50% suppression of lesion size) against L. braziliensis panamensis.
Original language | English (US) |
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Pages (from-to) | 918-921 |
Number of pages | 4 |
Journal | Antimicrobial Agents and Chemotherapy |
Volume | 34 |
Issue number | 5 |
DOIs | |
State | Published - 1990 |
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases