Beyond oncology - Application of HPMA copolymers in non-cancerous diseases

Xin Ming Liu; Scott C. Miller; Dong Wang

doi:10.1016/j.addr.2009.10.006

Beyond oncology - Application of HPMA copolymers in non-cancerous diseases

Xin Ming Liu, Scott C. Miller, Dong Wang

Research output: Contribution to journal › Review article › peer-review

39 Scopus citations

Abstract

Macromolecular drug conjugates have been developed to improve the efficacy and safety profile of various therapeutic agents for many years. Among them, N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-drug conjugates are the most extensively studied delivery platforms for the effective treatment of cancer. In recent years, the applications of HPMA copolymers for the treatment of a broader range of non-cancerous diseases have also been explored. This review highlights the recent developments in the rational design, synthesis, and evaluation of novel HPMA copolymer-drug conjugates for non-cancerous diseases, such as musculoskeletal diseases, infectious diseases and spinal cord injury. The translation potential of these applications is also briefly discussed.

Original language	English (US)
Pages (from-to)	258-271
Number of pages	14
Journal	Advanced Drug Delivery Reviews
Volume	62
Issue number	2
DOIs	https://doi.org/10.1016/j.addr.2009.10.006
State	Published - Feb 17 2010

Keywords

Arthritis
Bone-targeting
Central nervous system (CNS)
HPMA copolymers
Infectious diseases
Musculoskeletal diseases

ASJC Scopus subject areas

Pharmaceutical Science

Access to Document

10.1016/j.addr.2009.10.006

Cite this

@article{caa15f64c0ad4efcb9b18ea2af453aee,

title = "Beyond oncology - Application of HPMA copolymers in non-cancerous diseases",

abstract = "Macromolecular drug conjugates have been developed to improve the efficacy and safety profile of various therapeutic agents for many years. Among them, N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-drug conjugates are the most extensively studied delivery platforms for the effective treatment of cancer. In recent years, the applications of HPMA copolymers for the treatment of a broader range of non-cancerous diseases have also been explored. This review highlights the recent developments in the rational design, synthesis, and evaluation of novel HPMA copolymer-drug conjugates for non-cancerous diseases, such as musculoskeletal diseases, infectious diseases and spinal cord injury. The translation potential of these applications is also briefly discussed.",

keywords = "Arthritis, Bone-targeting, Central nervous system (CNS), HPMA copolymers, Infectious diseases, Musculoskeletal diseases",

author = "Liu, {Xin Ming} and Miller, {Scott C.} and Dong Wang",

note = "Funding Information: We want to express our heartfelt gratitude to all the colleagues who have contributed to the applications of HPMA copolymer research, especially in non-cancerous diseases. Due to the limitation of the manuscript length, many of their outstanding work are not included here. We also thank Dr. Kope{\v c}ek, as a great collaborator, a caring mentor and a dear friend, whose legendary contribution to the field has inspired many, including ourselves in pursuing polymer therapeutic research. The work is supported in part by NIH grant R01 AR053325 (to DW). ",

year = "2010",

month = feb,

day = "17",

doi = "10.1016/j.addr.2009.10.006",

language = "English (US)",

volume = "62",

pages = "258--271",

journal = "Advanced Drug Delivery Reviews",

issn = "0169-409X",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - Beyond oncology - Application of HPMA copolymers in non-cancerous diseases

AU - Liu, Xin Ming

AU - Miller, Scott C.

AU - Wang, Dong

N1 - Funding Information: We want to express our heartfelt gratitude to all the colleagues who have contributed to the applications of HPMA copolymer research, especially in non-cancerous diseases. Due to the limitation of the manuscript length, many of their outstanding work are not included here. We also thank Dr. Kopeček, as a great collaborator, a caring mentor and a dear friend, whose legendary contribution to the field has inspired many, including ourselves in pursuing polymer therapeutic research. The work is supported in part by NIH grant R01 AR053325 (to DW).

PY - 2010/2/17

Y1 - 2010/2/17

N2 - Macromolecular drug conjugates have been developed to improve the efficacy and safety profile of various therapeutic agents for many years. Among them, N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-drug conjugates are the most extensively studied delivery platforms for the effective treatment of cancer. In recent years, the applications of HPMA copolymers for the treatment of a broader range of non-cancerous diseases have also been explored. This review highlights the recent developments in the rational design, synthesis, and evaluation of novel HPMA copolymer-drug conjugates for non-cancerous diseases, such as musculoskeletal diseases, infectious diseases and spinal cord injury. The translation potential of these applications is also briefly discussed.

AB - Macromolecular drug conjugates have been developed to improve the efficacy and safety profile of various therapeutic agents for many years. Among them, N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-drug conjugates are the most extensively studied delivery platforms for the effective treatment of cancer. In recent years, the applications of HPMA copolymers for the treatment of a broader range of non-cancerous diseases have also been explored. This review highlights the recent developments in the rational design, synthesis, and evaluation of novel HPMA copolymer-drug conjugates for non-cancerous diseases, such as musculoskeletal diseases, infectious diseases and spinal cord injury. The translation potential of these applications is also briefly discussed.

KW - Arthritis

KW - Bone-targeting

KW - Central nervous system (CNS)

KW - HPMA copolymers

KW - Infectious diseases

KW - Musculoskeletal diseases

UR - http://www.scopus.com/inward/record.url?scp=75749129808&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=75749129808&partnerID=8YFLogxK

U2 - 10.1016/j.addr.2009.10.006

DO - 10.1016/j.addr.2009.10.006

M3 - Review article

C2 - 19909776

AN - SCOPUS:75749129808

SN - 0169-409X

VL - 62

SP - 258

EP - 271

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

IS - 2

ER -

Beyond oncology - Application of HPMA copolymers in non-cancerous diseases

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this