Beyond the eye: Cortical differences in primary visual processing in children with cerebral palsy

Jacy R. VerMaas, Christine M. Embury, Rashelle M. Hoffman, Michael P. Trevarrow, Tony W. Wilson, Max J. Kurz

Research output: Contribution to journalArticlepeer-review

Abstract

Despite the growing clinical recognition of visual impairments among people with cerebral palsy (CP), very few studies have evaluated the neurophysiology of the visual circuitry. To this end, the primary aim of this investigation was to use magnetoencephalography and beamforming methods to image the relative change in the alpha–beta and gamma occipital cortical oscillations induced by a spatial grating stimulus (e.g., visual contrast) that was viewed by a cohort of children with CP and typically-developing (TD) children. Our results showed that the high-contrast, visual gratings stimuli induced a decrease in alpha–beta (10 – 20 Hz) activity, and an increase in both low (40 – 56 Hz) and high (60 – 72 Hz) gamma oscillations in the occipital cortices. Compared with the TD children, the strength of the frequency specific cortical oscillations were significantly weaker in the children with CP, suggesting that they had deficient processing of the contrast stimulus. Although CP is largely perceived as a musculoskeletal centric disorder, our results fuel the growing impression that there may also be prominent visual processing deficiencies. These visual processing deficits likely impact the ability to perceive visual changes in the environment.

Original languageEnglish (US)
Article number102318
JournalNeuroImage: Clinical
Volume27
DOIs
StatePublished - 2020

Keywords

  • Contrast
  • MEG
  • Magnetoencephalography
  • Spatial gratings
  • Vision
  • Visual perception

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology
  • Cognitive Neuroscience

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