TY - JOUR
T1 - Beyond the eye
T2 - Cortical differences in primary visual processing in children with cerebral palsy
AU - VerMaas, Jacy R.
AU - Embury, Christine M.
AU - Hoffman, Rashelle M.
AU - Trevarrow, Michael P.
AU - Wilson, Tony W.
AU - Kurz, Max J.
N1 - Funding Information:
This work was partially supported by grants from the National Institutes of Health ( 5R01HD086245 ; 1R01HD101833 ; 1P20GM130447 ).
Publisher Copyright:
© 2020 The Authors
PY - 2020
Y1 - 2020
N2 - Despite the growing clinical recognition of visual impairments among people with cerebral palsy (CP), very few studies have evaluated the neurophysiology of the visual circuitry. To this end, the primary aim of this investigation was to use magnetoencephalography and beamforming methods to image the relative change in the alpha–beta and gamma occipital cortical oscillations induced by a spatial grating stimulus (e.g., visual contrast) that was viewed by a cohort of children with CP and typically-developing (TD) children. Our results showed that the high-contrast, visual gratings stimuli induced a decrease in alpha–beta (10 – 20 Hz) activity, and an increase in both low (40 – 56 Hz) and high (60 – 72 Hz) gamma oscillations in the occipital cortices. Compared with the TD children, the strength of the frequency specific cortical oscillations were significantly weaker in the children with CP, suggesting that they had deficient processing of the contrast stimulus. Although CP is largely perceived as a musculoskeletal centric disorder, our results fuel the growing impression that there may also be prominent visual processing deficiencies. These visual processing deficits likely impact the ability to perceive visual changes in the environment.
AB - Despite the growing clinical recognition of visual impairments among people with cerebral palsy (CP), very few studies have evaluated the neurophysiology of the visual circuitry. To this end, the primary aim of this investigation was to use magnetoencephalography and beamforming methods to image the relative change in the alpha–beta and gamma occipital cortical oscillations induced by a spatial grating stimulus (e.g., visual contrast) that was viewed by a cohort of children with CP and typically-developing (TD) children. Our results showed that the high-contrast, visual gratings stimuli induced a decrease in alpha–beta (10 – 20 Hz) activity, and an increase in both low (40 – 56 Hz) and high (60 – 72 Hz) gamma oscillations in the occipital cortices. Compared with the TD children, the strength of the frequency specific cortical oscillations were significantly weaker in the children with CP, suggesting that they had deficient processing of the contrast stimulus. Although CP is largely perceived as a musculoskeletal centric disorder, our results fuel the growing impression that there may also be prominent visual processing deficiencies. These visual processing deficits likely impact the ability to perceive visual changes in the environment.
KW - Contrast
KW - MEG
KW - Magnetoencephalography
KW - Spatial gratings
KW - Vision
KW - Visual perception
UR - http://www.scopus.com/inward/record.url?scp=85086915523&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85086915523&partnerID=8YFLogxK
U2 - 10.1016/j.nicl.2020.102318
DO - 10.1016/j.nicl.2020.102318
M3 - Article
C2 - 32604019
AN - SCOPUS:85086915523
SN - 2213-1582
VL - 27
JO - NeuroImage: Clinical
JF - NeuroImage: Clinical
M1 - 102318
ER -